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1.发明公开
公开(公告)号：EP3634408A1
公开(公告)日：2020-04-15
申请号：EP18812747.6
申请日：2018-06-04
发明人： CLAUSEN, Dane James , FELLS, James, I. , KOZLOWSKI, Joseph, A. , LIU, Ping , MAZZOLA, Robert, D., Jr.
IPC分类号： A61K31/439 , A61P11/00 , A61P29/00
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公开(公告)号：EP3197451A1
公开(公告)日：2017-08-02
申请号：EP15843799.6
申请日：2015-09-23
发明人： CAI, Jiaqiang , CRESPO, Alejandro , DU, Xiaoxing , DUBOIS, Byron Gabriel , LIU, Ping , LIU, Rongqiang , QUAN, Weiguo , SINZ, Christopher , WANG, Liping
IPC分类号： A61K31/4355
CPC分类号： C07D491/048 , A61P7/06 , A61P9/10
摘要： The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
摘要翻译： 本发明涉及抑制HIF脯氨酰羟化酶的式I化合物或其药学上可接受的盐，它们用于增强促红细胞生成素的内源性产生，以及用于治疗与促红细胞生成素内源性产生减少有关的病症，例如贫血等疾病，以及 包含这种化合物和药物载体的药物组合物。
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3.发明授权SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT 有权取代的环丙基的化合物，其具有这样的化合物和治疗方法的组合物THAT
公开(公告)号：EP2720544B1
公开(公告)日：2016-12-21
申请号：EP12800485.0
申请日：2012-06-11
发明人： MILLER, Michael , STAMFORD, Andrew , BASU, Kallol , WOOD, Harold, B. , DEMONG, Duane , SUN, Wanying , GARFUNKLE, Joie , MOYES, Christopher , HU, Zhiyong , LIU, Ping , EDMONDSON, Scott, D. , DAI, Xing , DUBOIS, Byron, Gabriel
IPC分类号： A01N43/40 , A61K31/445 , C07D405/14 , C07D413/14 , C07D417/14 , C07D211/22 , C07D211/24 , C07D401/04 , C07D401/14 , C07D413/04
CPC分类号： C07D211/24 , C07D211/22 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
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公开(公告)号：EP2780337A1
公开(公告)日：2014-09-24
申请号：EP12849788.0
申请日：2012-11-09
发明人： EDMONDSON, Scott , HU, Zhiyong , LIU, Ping , MORRIELLO, Gregori, J. , SZEWCZYK, Jason, W. , WANG, Bowei , WOOD, Harold, B. , ZHU, Cheng , ZHU, Yuping , GUO, Zhiqiang
IPC分类号： C07D401/00
CPC分类号： C07D513/04 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
摘要： Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included
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公开(公告)号：EP2780337B1
公开(公告)日：2017-12-20
申请号：EP12849788.0
申请日：2012-11-09
发明人： EDMONDSON, Scott , HU, Zhiyong , LIU, Ping , MORRIELLO, Gregori, J. , SZEWCZYK, Jason, W. , WANG, Bowei , WOOD, Harold, B. , ZHU, Cheng , ZHU, Yuping , GUO, Zhiqiang
IPC分类号： C07D401/00
CPC分类号： C07D513/04 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
摘要： Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
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公开(公告)号：EP3197455A1
公开(公告)日：2017-08-02
申请号：EP15845304.3
申请日：2015-09-23
发明人： CAI, Jiaqiang , COLANDREA, Vincent , CRESPO, Alejandro , DEBENHAM, John , DU, Xiaoxing , GUIADEEN, Deodialsingh , LIU, Ping , LIU, Rongqiang , MADSEN-DUGGAN, Cristina, B. , MCCOY, Joshua, G. , QUAN, Weiguo , SINZ, Christopher , WANG, Liping
IPC分类号： A61K31/4704
CPC分类号： C07D491/052 , C07D215/56 , C07D221/22 , C07D417/06 , C07D471/04
摘要： The present invention concerns a compound of formula I or a pharmaceutically acceptable salt thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
摘要翻译： 本发明涉及抑制HIF脯氨酰羟化酶的式I化合物或其药学上可接受的盐，它们用于增强促红细胞生成素的内源性产生，以及用于治疗与促红细胞生成素内源性产生减少相关的疾病如贫血等疾病， 以及包含这种化合物和药物载体的药物组合物。
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7.发明授权SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 有权取代的环丙基化合物，含有这些化合物的组合物和治疗方法
公开(公告)号：EP2693882B1
公开(公告)日：2017-06-28
申请号：EP12767881.1
申请日：2012-04-05
发明人： EDMONDSON, Scott , GUO, Zhiqiang , GEISS, William, B. , WOOD, Harold, B. , STAMFORD, Andrew, W. , MILLER, Michael, W. , DEMONG, Duane, E. , MORRIELLO, Gregori, J. , ANAND, Rajan , COLANDREA, Vincent, J. , MACALA, Megan , MALETIC, Milana , ZHU, Cheng , ZHU, Yuping , SUN, Wanying , ZHAO, Kake , HUANG, Yong , HARRIS, Joel, M. , CHANG, Lehua , KAR, Nam Fung , HU, Zhiyong , WANG, Liping , WANG, Bowei , LIU, Ping , SZEWCZYK, Jason, W.
IPC分类号： C07D211/22 , C07D401/12 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/506 , A61P5/50
CPC分类号： C07D513/04 , A61K9/4858 , C07D211/22 , C07D401/12 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
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公开(公告)号：EP3122343A2
公开(公告)日：2017-02-01
申请号：EP15767840.0
申请日：2015-03-23
发明人： MITCHELL, Helen , FRALEY, Mark, E. , COOKE, Andrew, J. , STUMP, Craig, A. , ZHANG, Xu-Fang , MCCOMAS, Casey, C. , SCHIRRIPA, Kathy , MCWHERTER, Melody , LIU, Ping , PARKER, Dann , LI, Chun Sing , MAO, Qinghua
IPC分类号： A61K31/166
CPC分类号： C07D487/04 , C07D231/40 , C07D277/46 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to substituted five membered heteroaryl benzamide compounds of formula (I) (Formula (I)) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
摘要翻译： 本发明涉及作为原肌球蛋白相关激酶（Trk）家族蛋白激酶抑制剂的式（I）（式（I））的取代的五元杂芳基苯甲酰胺化合物，因此可用于治疗疼痛，炎症，癌症 ，再狭窄，动脉粥样硬化，银屑病，血栓形成，与髓鞘形成障碍或神经生长因子（NGF）受体TrkA异常活性相关的疾病或病症有关的疾病，病症，损伤或功能障碍。
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公开(公告)号：EP2900242A1
公开(公告)日：2015-08-05
申请号：EP13842584.8
申请日：2013-09-25
发明人： ACTON, John, J. , EDMONDSON, Scott, D. , LIU, Ping , MILLER, Michael, W. , WOOD, Harold, B. , DUBOIS, Byron, G. , GEISS, William, B.
IPC分类号： A61K31/506 , A61P3/10 , C07D401/04
CPC分类号： C07D211/60 , A61K31/506 , C07D211/22 , C07D401/04 , C07D401/12 , C07D401/14 , C07D413/04 , C07D413/14
摘要： Substituted cyclopropyl piperidinyl compounds and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-1 19. Pharmaceutical compositions and methods of treatment are also included.
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10.发明公开SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT 有权取代的环丙基化合物，含有这种化合物的组合物以及治疗方法
公开(公告)号：EP2720544A1
公开(公告)日：2014-04-23
申请号：EP12800485.0
申请日：2012-06-11
发明人： MILLER, Michael , STAMFORD, Andrew , BASU, Kallol , WOOD, Harold, B. , DEMONG, Duane , SUN, Wanying , GARFUNKLE, Joie , MOYES, Christopher , HU, Zhiyong , LIU, Ping , EDMONDSON, Scott, D. , DAI, Xing , DUBOIS, Byron, Gabriel
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： C07D211/24 , C07D211/22 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 公开的式I的取代环丙基化合物及其药学上可接受的盐公开用于治疗或预防2型糖尿病和类似病症。 该化合物可用作G蛋白偶联受体GPR-119的激动剂。 药物组合物和治疗方法也包括在内。
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