- 专利标题: SELECTION OF FAB FRAGMENTS USING RIBOSOMAL DISPLAY TECHNOLOGY
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申请号: EP14788445.6申请日: 2014-04-23
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公开(公告)号: EP2989239B1公开(公告)日: 2018-07-04
- 发明人: STAFFORD, Ryan , THANOS, Christopher, D
- 申请人: Sutro Biopharma, Inc.
- 申请人地址: 310 Utah Avenue, Suite 150 South San Francisco, California 94080 US
- 专利权人: Sutro Biopharma, Inc.
- 当前专利权人: Sutro Biopharma, Inc.
- 当前专利权人地址: 310 Utah Avenue, Suite 150 South San Francisco, California 94080 US
- 代理机构: J A Kemp
- 优先权: US201361816075P 20130425
- 国际公布: WO2014176327 20141030
- 主分类号: C40B10/00
- IPC分类号: C40B10/00 ; C40B20/04 ; C40B40/02 ; C40B40/08
摘要:
The invention relates to a method for generating and selecting Fab fragments using ribosomal display and cell-free protein synthesis. The invention also provides a ribosomal display reaction system for generating Fab fragment complexes. The compositions of a Fab fragment complex and a library thereof are also provided.
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