发明公开
EP3003387A1 COMPOSITIONS AND METHODS FOR CONJUGATING ACTIVATABLE ANTIBODIES
审中-公开
ZUSAMMENSETZUNGEN UND VERFAHREN ZUR KONJUGIERUNG AKTIVIERBARERANTIKÖRPER
- 专利标题: COMPOSITIONS AND METHODS FOR CONJUGATING ACTIVATABLE ANTIBODIES
- 专利标题(中): ZUSAMMENSETZUNGEN UND VERFAHREN ZUR KONJUGIERUNG AKTIVIERBARERANTIKÖRPER
-
申请号: EP14733931.1申请日: 2014-06-04
-
公开(公告)号: EP3003387A1公开(公告)日: 2016-04-13
- 发明人: KONRADI, Andrei William , SINGH, Shweta , LOWMAN, Henry Bernard , DESNOYERS, Luc Roland , LIANG, Tony W.
- 申请人: Cytomx Therapeutics Inc.
- 申请人地址: 343 Oyster Point Blvd Suite 100 South San Francisco, CA 94080-1913 US
- 专利权人: Cytomx Therapeutics Inc.
- 当前专利权人: Cytomx Therapeutics Inc.
- 当前专利权人地址: 343 Oyster Point Blvd Suite 100 South San Francisco, CA 94080-1913 US
- 代理机构: Cooley (UK) LLP
- 优先权: US201361830913P 20130604; US201361919935P 20131223
- 国际公布: WO2014197612 20141211
- 主分类号: A61K47/48
- IPC分类号: A61K47/48 ; A61P35/00
摘要:
The invention relates generally to compositions and methods for conjugating antibodies and activatable antibodies, and methods of partially reducing antibodies and/or activatable antibodies prior to conjugation, e.g., thiol-based conjugation, with an agent, e.g., a therapeutic and/or diagnostic agent.
信息查询