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公开(公告)号：EP4412635A1
公开(公告)日：2024-08-14
申请号：EP22809608.7
申请日：2022-10-06
发明人： BEREZHNOY, Alexey Yevgenyevich , PUYADE, Nicole G. , CAI, Na , WINTER, Michael B. , WONG, Kenneth , PAIDHUNGAT, Madan M. , DANIEL, Dylan L. , LE SCOLAN, Erwan
CPC分类号： C07K19/00 , A61P35/00 , C07K16/2827 , A61K39/39558 , C07K14/52 , C07K2319/0020130101 , A61K39/39 , A61K45/06 , A61K38/21
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公开(公告)号：EP4132656A1
公开(公告)日：2023-02-15
申请号：EP21722709.9
申请日：2021-04-09
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3.发明公开
公开(公告)号：EP3983439A1
公开(公告)日：2022-04-20
申请号：EP20737644.3
申请日：2020-06-12
发明人： HUMPHREY, Rachel , WILL, Matthias , YARON, Yifah
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
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4.发明公开
公开(公告)号：EP3788077A1
公开(公告)日：2021-03-10
申请号：EP19727548.0
申请日：2019-05-02
IPC分类号： C07K16/28 , C07K14/705 , A61P35/00
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公开(公告)号：EP1324771B2
公开(公告)日：2018-06-06
申请号：EP01974480.4
申请日：2001-10-09
发明人： WALDMANN, Herman , FREWIN, Mark Raymond , GILLILAND, Lisa Kim , DA SILVA GRACA, Luis Richardo Simoes
IPC分类号： A61K39/395 , C07K19/00
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6.发明公开ANTI-ITGA3 ANTIBODIES, ACTIVATABLE ANTI-ITGA3 ANTIBODIES, AND METHODS OF USE THEREOF 审中-公开抗ITGA3抗体，活化抗ITGA3抗体及其使用方法
公开(公告)号：EP3292151A1
公开(公告)日：2018-03-14
申请号：EP16722507.7
申请日：2016-05-04
发明人： SAGERT, Jason Gary , TERRETT, Jonathan Alexander , DESNOYERS, Luc Roland , SINGH, Shweta , WEAVER, Annie Yang
CPC分类号： C07K16/2839 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K7/08 , C07K16/2842 , C07K16/30 , C07K2317/24 , C07K2317/33 , C07K2317/732 , C07K2317/92 , C07K2319/00 , C07K2319/50
摘要： The invention relates generally to antibodies that bind ITGa3, activatable antibodies that specifically bind to ITGa3 and methods of making and using these anti-ITGa3 antibodies and anti-ITGa3 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
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7.发明公开COMPOSITIONS AND METHODS FOR CONJUGATING ACTIVATABLE ANTIBODIES 审中-公开ZUSAMMENSETZUNGEN UND VERFAHREN ZUR KONJUGIERUNG AKTIVIERBARERANTIKÖRPER
公开(公告)号：EP3003387A1
公开(公告)日：2016-04-13
申请号：EP14733931.1
申请日：2014-06-04
发明人： KONRADI, Andrei William , SINGH, Shweta , LOWMAN, Henry Bernard , DESNOYERS, Luc Roland , LIANG, Tony W.
CPC分类号： A61K47/48715 , A61K39/3955 , A61K47/6803 , A61K47/6851 , A61K47/6889 , A61K49/00 , A61K2039/505 , C07K16/18 , C07K16/2863 , C07K2317/21 , C07K2317/76
摘要： The invention relates generally to compositions and methods for conjugating antibodies and activatable antibodies, and methods of partially reducing antibodies and/or activatable antibodies prior to conjugation, e.g., thiol-based conjugation, with an agent, e.g., a therapeutic and/or diagnostic agent.
摘要翻译： 本发明一般涉及用于结合抗体和可激活抗体的组合物和方法，以及在缀合之前部分还原抗体和/或可激活抗体的方法，例如基于硫醇的缀合，与试剂，例如治疗和/或诊断剂 。
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8.发明公开COMPOSITIONS AND METHODS FOR DETECTING PROTEASE ACTIVITY IN BIOLOGICAL SYSTEMS 审中-公开组合物和方法蛋白酶活性的生物系统检测
公开(公告)号：EP2941643A2
公开(公告)日：2015-11-11
申请号：EP14735246.2
申请日：2014-01-03
IPC分类号： G01N33/48 , C12P21/08 , A61K39/395
CPC分类号： G01N33/573 , A61K47/6849 , A61K47/6855 , A61K47/6889 , A61K49/0021 , A61K49/0058 , C07K16/2863 , C07K16/2896 , C07K2319/50 , C07K2319/60 , G01N33/57484 , G01N2333/95
摘要： The invention relates generally to compositions and methods for detecting protease activity in a subject or a biological sample using activatable antibodies, and the use of these compositions and methods in a variety of diagnostic indications.
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9.发明公开ANTI-JAGGED 1/JAGGED 2 CROSS-REACTIVE ANTIBODIES, ACTIVATABLE ANTI-JAGGED ANTIBODIES AND METHODS OF USE THEREOF 审中-公开ANG-JAGGED-1 / JAGGED-2-KREUZREAKTIVEANTIKÖRPER，AKTIVIERBARE ANTI-JAGGED-ANTIKÖRPERUND ANWENDUNGSVERFAHRENDAFÜR
公开(公告)号：EP2863948A2
公开(公告)日：2015-04-29
申请号：EP13807400.0
申请日：2013-06-21
发明人： WEST, James, William , SAGERT, Jason, Gary , BESSETTE, Paul, H. , LOWMAN, Henry, Bernard , STAGLIANO, Nancy, E. , VASILJEVA, Olga , MENENDEZ, Elizabeth-Edna, Mary
IPC分类号： A61K39/395 , A61P35/00 , C07K16/18
CPC分类号： C07K16/18 , A61K39/39558 , A61K47/48384 , A61K47/48415 , A61K47/48569 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K49/0058 , A61K2039/505 , C07K16/28 , C07K16/2887 , C07K16/2896 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/50 , A61K2300/00
摘要： This invention relates generally to the generation of antibodies,
e.g. , monoclonal antibodies including fully human monoclonal antibodies, that recognize Jagged 1 and/or Jagged 2, to antibodies,
e.g ., monoclonal antibodies including fully human antibodies that recognize Jagged 1 and/or Jagged 2, and nucleic acid molecules that encode antibodies,
e.g. , nucleic acid molecules that encode monoclonal antibodies including fully human cross-reactive antibodies that recognize both Jagged 1 and Jagged 2, and to methods of making the anti- Jagged antibodies and methods of using the anti- Jagged antibodies as therapeutics, prophylactics, and diagnostics. The invention also relates generally to activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically bind to Jagged 1 and Jagged 2, and to methods of making and using these activatable anti- Jagged antibodies in a variety of therapeutic, diagnostic and prophylactic indications.摘要翻译： 本发明一般涉及将抗体（例如，将完整的人单克隆抗体（包括完整的人单克隆抗体）识别Jagged 1和/或Jagged 2）生成到抗体，例如包括识别Jagged 1和/或Jagged 2的完全人抗体的单克隆抗体 和编码抗体的核酸分子，例如编码单克隆抗体的核酸分子，包括识别Jagged 1和Jagged 2的完全人交叉反应性抗体，以及制备抗锯齿抗体的方法和使用抗锯齿抗体的方法 - 抗体作为治疗，预防和诊断。 本发明还通常涉及可激活的抗体，其包括特异性结合锯齿状1和锯齿状2的掩蔽部分（MM），可切割部分（CM）和抗体（AB），以及制备和使用这些可激活的抗体 - 各种治疗，诊断和预防指征中的锯齿状抗体。
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公开(公告)号：EP4416180A1
公开(公告)日：2024-08-21
申请号：EP22802454.3
申请日：2022-10-14
发明人： BOUSTANY, Leila M. , PAIDHUNGAT, Madan M. , FOX, Ellaine Anne Mariano , MITRA, Sayantan , KAVANAUGH, W. Michael , BRIANTE, Raffaella , STEVENS, Jennitte LeAnn
IPC分类号： C07K16/28
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