发明公开
- 专利标题： NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS
- 专利标题（中）： 新颖的化合物，其药物组合物炎症性疾病的治疗
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申请号： EP14729895.4申请日： 2014-06-12
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公开(公告)号： EP3010922A1公开(公告)日： 2016-04-27
- 发明人: DESROY, Nicolas , HECKMANN, Bertrand , BRYS, Reginald Christophe Xavier , JONCOUR, Agnès Marie , PEIXOTO, Christophe , BOCK, Xavier Marie , HOUSSEMAN, Christopher Gaëtan
- 申请人： Galapagos NV
- 申请人地址： Industriepark Mechelen Noord Generaal De Wittelaan L11 A3 2800 Mechelen BE
- 专利权人： Galapagos NV
- 当前专利权人： Galapagos NV
- 当前专利权人地址： Industriepark Mechelen Noord Generaal De Wittelaan L11 A3 2800 Mechelen BE
- 代理机构： Bar, Grégory
- 优先权： US201361836831P 20130619
- 国际公布： WO2014202458 20141224
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D519/00 ; A61K31/4985 ; A61K31/5025
摘要：
The present invention discloses compounds according to Formula I: Wherein R1a, R1b, R2, R4, R5, R6, R7, R8, W, X, Y, Z, Cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseases by administering the compound of the invention.
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