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1.发明公开
公开(公告)号：EP3681864A1
公开(公告)日：2020-07-22
申请号：EP18779798.0
申请日：2018-09-13
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , COUTY, Sylvain , DESROY, Nicolas , GFESSER, Gregory A. , HOUSSEMAN, Christopher Gaëtan , KYM, Philip R. , LIU, Bo , MAI, Thi Thu Trang , MALAGU, Karine Fabienne , MERAYO MERAYO, Nuria , PICOLET, Olivier Laurent , PIZZONERO, Mathieu Rafaël , SEARLE, Xenia B. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D213/71 , C07D215/36 , C07D231/56 , C07D401/12 , C07D235/28 , C07D471/04 , C07D213/64 , C07C311/45 , A61P11/00 , A61K31/4709
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公开(公告)号：EP3717471A1
公开(公告)日：2020-10-07
申请号：EP18811769.1
申请日：2018-11-26
申请人： Galapagos NV
发明人： ALVEY, Luke, Jonathan , ANNOOT, Denis, Maurice , BONNATERRE, Florence, Marie-Emilie , BUCHER, Denis , DUTHION, Béranger , JARY, Hélène, Marie , PEIXOTO, Christophe , TEMAL-LAIB, Taoues , TIRERA, Amynata , DESROY, Nicolas
IPC分类号： C07D403/04 , C07D471/04 , A61K31/437 , A61P9/00 , A61P37/00
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公开(公告)号：EP3523277A1
公开(公告)日：2019-08-14
申请号：EP17794414.7
申请日：2017-10-04
申请人： Abbvie S.a.r.l. , Galapagos NV
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , DESROY, Nicolas , GFESSER, Gregory A. , GRESZLER, Stephen N. , KOENIG, John R. , KYM, Philip R. , LIU, Bo , SCANIO, Marc J. , SEARLE, Xenia , WANG, Xueqing , YEUNG, Ming C. , ZHAO, Gang
IPC分类号： C07D207/16 , C07D401/12 , A61K31/4025 , A61K31/4439 , A61P11/00
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公开(公告)号：EP3359539A1
公开(公告)日：2018-08-15
申请号：EP16785567.5
申请日：2016-10-07
申请人： AbbVie S.À.R.L. , Galapagos NV
发明人： AKKARI, Rhalid , ALVEY, Luke Jonathan , BOCK, Xavier Marie , CLAES, Pieter Isabelle Roger , COWART, Marlon D. , DE LEMOS, Elsa , DESROY, Nicolas , DUTHION, Béranger , GFESSER, Gregory A. , GOSMINI, Romain Luc Marie , HOUSSEMAN, Christopher Gaëtan , JANSEN, Koen Karel , JI, Jianguo , KYM, Philip R. , LEFRANCOIS, Jean-Michel , MAMMOLITI, Oscar , MENET, Christel Jeanne Marie , NEWSOME, Gregory John Robert , PALISSE, Adeline Marie Elise , PATEL, Sachin V. , PIZZONERO, Mathieu Rafaël , SHRESTHA, Anurupa , SWIFT, Elizabeth C. , VAN DER PLAS, Steven Emiel , WANG, Xueqing
IPC分类号： C07D471/04 , A61K31/437 , A61P11/12 , C07D519/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： wherein R1, R2, R3, and R4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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5.发明公开
公开(公告)号：EP3585784A1
公开(公告)日：2020-01-01
申请号：EP18710151.4
申请日：2018-02-23
申请人： Abbvie S.a.r.l. , Galapagos NV
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , DESROY, Nicolas , GFESSER, Gregory A. , GRESZLER, Stephen N. , KYM, Philip R. , LIU, Bo , MALAGU, Karine Fabienne , MERAYO MERAYO, Nuria , PIZZONERO, Mathieu Rafaël , SEARLE, Xenia B. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , YEUNG, Ming C. , ZHAO, Gang
IPC分类号： C07D405/12 , C07D407/12 , C07D319/22 , C07D307/16 , A61P3/04 , A61K31/381 , A61K31/343
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6.发明授权
公开(公告)号：EP2970255B9
公开(公告)日：2018-09-19
申请号：EP14708291.1
申请日：2014-03-07
申请人： Galapagos NV
发明人： DESROY, Nicolas , HECKMANN, Bertrand , BRYS, Reginald Christophe Xavier , JONCOUR, Agnès , PEIXOTO, Christophe , BOCK, Xavier
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P37/00 , A61P29/00 , A61P25/28 , A61P11/00 , A61P9/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
摘要： The present invention discloses compounds according to Formula I: Wherein R 1a , R 1b , R 2 , R 4 , R 5 , R 6a , R 6b , R 7 , R 8 , W, X, Cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseases by administering the compound of the invention.
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公开(公告)号：EP3359541A1
公开(公告)日：2018-08-15
申请号：EP16788232.3
申请日：2016-10-07
申请人： AbbVie S.À.R.L. , Galapagos NV
发明人： AKKARI, Rhalid , ALVEY, Luke Jonathan , BOCK, Xavier Marie , BROWN, Brian S. , CLAES, Pieter Isabelle Roger , COWART, Marlon D. , DE LEMOS, Elsa , DESROY, Nicolas , DUTHION, Béranger , GFESSER, Gregory A. , GOSMINI, Romain Luc Marie , HOUSSEMAN, Christopher Gaëtan , JANSEN, Koen Karel , JI, Jianguo , KYM, Philip R. , LEFRANCOIS, Jean-Michel , MAMMOLITI, Oscar , MENET, Christel Jeanne Marie , MERAYO, Nuria Merayo , NEWSOME, Gregory John Robert , PALISSE, Adeline Marie Elise , PATEL, Sachin V. , PIZZONERO, Mathieu Rafaël , SHRESTHA, Anurupa , SWIFT, Elizabeth C. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , DE BLIECK, Ann
IPC分类号： C07D471/04 , A61K31/437 , A61P11/12 , C07D519/00
摘要： wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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公开(公告)号：EP3359540A1
公开(公告)日：2018-08-15
申请号：EP16785568.3
申请日：2016-10-07
申请人： AbbVie S.À.R.L. , Galapagos NV
发明人： AKKARI, Rhalid , ALVEY, Luke Jonathan , BOCK, Xavier Marie , BROWN, Brian S. , CLAES, Pieter Isabelle Roger , COWART, Marlon D. , CONRATH, Katja E. , CYR, Douglas , DE LEMOS, Elsa , DE WILDE, Gert Jules Hector , DESROY, Nicolas , DUTHION, Béranger , GFESSER, Gregory A. , GOSMINI, Romain Luc Marie , HOUSSEMAN, Christopher Gaëtan , JANSEN, Koen Karel , JI, Jianguo , KYM, Philip R. , LEFRANCOIS, Jean-Michel , MAMMOLITI, Oscar , MENET, Christel Jeanne Marie , MERAYO, Nuria Merayo , NEWSOME, Gregory John Robert , PALISSE, Adeline Marie Elise , PATEL, Sachin V. , PIZZONERO, Mathieu Rafaël , SHRESTHA, Anurupa , SWIFT, Elizabeth C. , TSE, Chris , VAN DER PLAS, Steven Emiel , WANG, Xueqing
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61P11/00 , G01N33/68
CPC分类号： A61K31/4545 , A61K45/06 , C07D471/04 , C07D519/00 , G01N33/5023 , G01N2800/382
摘要： A corrector agent capable of stabilizing a newly synthesized cystic fibrosis transmembrane conductance regulator (CFTR) protein, useful in the treatment of cystic fibrosis.
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9.发明授权
公开(公告)号：EP2970255B1
公开(公告)日：2017-08-02
申请号：EP14708291.1
申请日：2014-03-07
申请人： Galapagos NV
发明人： DESROY, Nicolas , HECKMANN, Bertrand , BRYS, Reginald Christophe Xavier , JONCOUR, Agnès , PEIXOTO, Christophe , BOCK, Xavier
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P37/00 , A61P29/00 , A61P25/28 , A61P11/00 , A61P9/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
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10.发明公开
公开(公告)号：EP3806853A1
公开(公告)日：2021-04-21
申请号：EP19729465.5
申请日：2019-05-29
申请人： Galapagos NV
发明人： DESROY, Nicolas , JONCOUR, Agnès, Marie , PEIXOTO, Christophe , TEMAL-LAIB, Taoues , TIRERA, Amynata , BUCHER, Denis , AMANTINI, David , DE VOS, Steve, Irma, Joel , BRYS, Reginald, Christophe, Xavier
IPC分类号： A61K31/437 , C07D471/04 , A61P25/00 , A61P11/00 , A61P9/00 , A61P35/00 , A61P37/00
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