发明公开
- 专利标题： PRIMARY CARBOXAMIDES AS BTK INHIBITORS
- 专利标题（中）： PRIMÄRECARBOXAMIDE ALS BTK-HEMMER
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申请号： EP14817453.5申请日： 2014-06-26
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公开(公告)号： EP3013337A1公开(公告)日： 2016-05-04
- 发明人: BONAFOUX, Dominique , DAVIS, Heather, M. , FRANK, Kristine, E. , FRIEDMAN, Michael, M. , HEROLD, J., Martin , HOEMANN, Michael, Z. , HUNTLEY, Raymond , OSUMA, Augustine , SHEPPARD, George , SOMAL, Gagandeep, K. , VAN CAMP, Jennifer , VAN EPPS, Stacy, A. , VASUDEVAN, Anil , WALLACE, Grier, A. , WANG, Lu , WANG, Lu , WANG, Zhi , WILSON, Noel, S. , XU, Xiangdong
- 申请人： Abbvie Inc.
- 申请人地址： 1 North Waukegan Road North Chicago, IL 60064 US
- 专利权人： Abbvie Inc.
- 当前专利权人： Abbvie Inc.
- 当前专利权人地址： 1 North Waukegan Road North Chicago, IL 60064 US
- 代理机构： Reitstötter Kinzebach
- 优先权： US201361839729P 20130626; US201361897577P 20131030
- 国际公布： WO2014210255 20141231
- 主分类号： A61K31/405
- IPC分类号： A61K31/405 ; A61K31/454 ; A61K31/4545 ; C07D217/22
摘要：
The invention provides carboxamide compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions, including rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, Crohn's disease, inflammatory bowel disease, ulcerative colitis, psoriatic arthritis, psoriasis, ankylosing spondylitis, interstitial cystitis, asthma, systemic lupus erythematosus, lupus nephritis, B cell chronic lymphocytic lymphoma, multiple sclerosis, chronic lymphocytic leukemia, small lymphocytic lymphoma, mantle cell lymphoma, B-cell non-Hodgkin's lymphoma, activated B-celllike diffuse large B-cell, lymphoma, multiple myeloma, diffuse large B-celllymphoma, follicular lymphoma, hairy cell leukemia or Lymphoblastic lymphoma.
公开/授权文献
- EP3013337B1 PRIMARY CARBOXAMIDES AS BTK INHIBITORS 公开/授权日：2018-10-31
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