THERAPEUTIC DLL4 BINDING PROTEINS
    10.
    发明公开

    公开(公告)号:EP3680253A2

    公开(公告)日:2020-07-15

    申请号:EP20150745.6

    申请日:2011-02-28

    申请人: AbbVie Inc.

    IPC分类号: C07K16/18

    摘要: DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.