发明公开
EP3019480A1 2,4- OR 4,6-DIAMINOPYRIMIDINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER
审中-公开
2,4-或4,6-二氨基嘧啶类化合物作为IDH2突变体抑制剂用于治疗癌症
- 专利标题： 2,4- OR 4,6-DIAMINOPYRIMIDINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER
- 专利标题（中）： 2,4-或4,6-二氨基嘧啶类化合物作为IDH2突变体抑制剂用于治疗癌症
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申请号： EP14745308.8申请日： 2014-07-10
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公开(公告)号： EP3019480A1公开(公告)日： 2016-05-18
- 发明人: KONTEATIS, Zenon, D. , POPOVICI-MULLER, Janeta , TRAVINS, Jeremy
- 申请人： Agios Pharmaceuticals, Inc.
- 申请人地址： 88 Sidney Street Cambridge, Massachusetts 02139 US
- 专利权人： Agios Pharmaceuticals, Inc.
- 当前专利权人： Agios Pharmaceuticals, Inc.
- 当前专利权人地址： 88 Sidney Street Cambridge, Massachusetts 02139 US
- 代理机构： Harris, Jennifer Lucy
- 优先权： US201361845286P 20130711
- 国际公布： WO2015006591 20150115
- 主分类号： C07D239/48
- IPC分类号： C07D239/48 ; C07D401/04 ; C07D401/12 ; C07D401/14 ; C07D403/04 ; C07D403/12 ; C07D405/12 ; C07D405/14 ; C07D413/04 ; C07D413/12 ; C07D413/14 ; C07D417/04 ; C07D417/12 ; C07D493/08 ; A61K31/505 ; A61P35/00
摘要：
Provided are compounds of formula (I), wherein: ring A and ring B are each independently an optionally substituted 5-6 membered monocyclic aryl or heteroaryl; one of X, Y and W is CH and the two others are N; and Z is H or —C(R1)(R2)(R3). The compounds are inhibitors of isocitrate dehydronenase 2 (IDH2) mutants useful for treating cancer.
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