发明公开
EP3026435A1 Diagnostic prediction of caries risk by saliva marker analysis
审中-公开
Diagnostische Prognose des Kariesrisikos mittels Speichelmarkeranalyse
- 专利标题： Diagnostic prediction of caries risk by saliva marker analysis
- 专利标题（中）： Diagnostische Prognose des Kariesrisikos mittels Speichelmarkeranalyse
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申请号： EP14195383.6申请日： 2014-11-28
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公开(公告)号： EP3026435A1公开(公告)日： 2016-06-01
- 发明人: Mira Obrador, Alejandro , Soro Áurea, Simón
- 申请人： Fundación Para El Fomento De La Investigación Sanitaria Y Biomédica De La Comunitat Valenciana
- 申请人地址： C/ Micer Mascó 31 46010 Valencia ES
- 专利权人： Fundación Para El Fomento De La Investigación Sanitaria Y Biomédica De La Comunitat Valenciana
- 当前专利权人： Fundación Para El Fomento De La Investigación Sanitaria Y Biomédica De La Comunitat Valenciana
- 当前专利权人地址： C/ Micer Mascó 31 46010 Valencia ES
- 代理机构： Illescas, Manuel
- 主分类号： G01N33/68
- IPC分类号： G01N33/68 ; G01N33/84
摘要：
The present invention discloses a method for predicting caries risk in a subject and a kit based on said method, characterized in that said method comprises:
(a) determining the concentration in saliva from said subject of at least one compound selected from each of salivary components (i) of the immune system, (ii) involved in microbial adhesion to a surface of the buccal cavity; and (iii) involved in metabolism in the buccal cavity or in regulating the pH thereof;
(b) comparing a response variable calculated from more than one concentration determined in step (a) with a corresponding reference response variable in a population of subjects without caries or in a population of subjects with caries; and
(c) determining caries risk based on the degree of difference in response variable compared in step (b), wherein a greater degree of difference between the response variable of the subject and the corresponding reference response variable in a population of subjects without caries or in a population of subjects with caries, is indicative of higher caries risk in said subject.
(a) determining the concentration in saliva from said subject of at least one compound selected from each of salivary components (i) of the immune system, (ii) involved in microbial adhesion to a surface of the buccal cavity; and (iii) involved in metabolism in the buccal cavity or in regulating the pH thereof;
(b) comparing a response variable calculated from more than one concentration determined in step (a) with a corresponding reference response variable in a population of subjects without caries or in a population of subjects with caries; and
(c) determining caries risk based on the degree of difference in response variable compared in step (b), wherein a greater degree of difference between the response variable of the subject and the corresponding reference response variable in a population of subjects without caries or in a population of subjects with caries, is indicative of higher caries risk in said subject.
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