利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.016 秒)

    IN-VITRO METHOD AND KIT FOR DIAGNOSING THE RISK OF SUFFERING FROM CARIES
    2.
    发明公开
    IN-VITRO METHOD AND KIT FOR DIAGNOSING THE RISK OF SUFFERING FROM CARIES 审中-公开
    用于诊断罹患龋病风险的体内方法和试剂盒

    公开(公告)号：EP3229020A1

    公开(公告)日：2017-10-11

    申请号：EP15862543.4

    申请日：2015-11-27

    申请人： Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana

    发明人： MIRA OBRADOR, Alejandro ,  SIMÓN SORO, Áurea

    IPC分类号： G01N33/487 ,  G01N33/52 ,  G01N33/68

    CPC分类号： G01N33/6893 ,  G01N33/68 ,  G01N33/84 ,  G01N2800/18 ,  G01N2800/60

    摘要： The invention describes a method of predicting the risk of caries in a subject and a kit based on said method, characterized in that the method involves the following steps:
    (a) determining the concentration in the saliva of the subject of: (i) at least one compound selected from among the components of the saliva of the immune system; (ii) at least one compound selected from among those involved in microbial adhesion to a surface of the buccal cavity; and (iii) at least one compound selected from among the components involved in the metabolism or regulation of pH in the buccal cavity;
    (b) comparing a response variable calculated on the basis of the at least one of the concentrations determined in (i), at least one of the concentrations determined in (ii), and at least one of the concentrations determined in (iii) in step (a) with a corresponding reference response variable in a population of subjects without caries or in a population of subjects with caries; and
    (c) determining the risk of caries on the basis of the degree of difference in the response variable compared in step (b), wherein a higher degree of difference between the response variable of the subject and the corresponding reference response variable in a population of subjects without caries or in a population of subjects with caries is indicative of a higher risk of caries in said subject.

    摘要翻译： 本发明描述了基于所述方法预测受试者中龋齿风险的方法和试剂盒，其特征在于该方法包括以下步骤：（a）确定受试者唾液中的浓度：（i）在 选自免疫系统唾液组分中的至少一种化合物; （ii）至少一种选自微生物粘附到颊腔表面的化合物; 和（iii）至少一种选自参与代谢或调节颊腔pH值的成分的化合物; （b）比较基于（i）中确定的至少一种浓度，（ii）中确定的至少一种浓度和（iii）中确定的至少一种浓度计算的响应变量 步骤（a）在具有龋齿的受试者群体中或在具有龋齿的受试者群体中具有相应的参考响应变量; 和（c）基于步骤（b）中比较的响应变量的差异程度确定龋齿风险，其中所述受试者的响应变量与群体中的相应参考响应变量之间的较高程度的差异 没有龋齿的受试者或龋齿受试者群体表明所述受试者龋齿的风险较高。

    Diagnostic prediction of caries risk by saliva marker analysis
    3.
    发明公开
    Diagnostic prediction of caries risk by saliva marker analysis 审中-公开
    Diagnostische Prognose des Kariesrisikos mittels Speichelmarkeranalyse

    公开(公告)号：EP3026435A1

    公开(公告)日：2016-06-01

    申请号：EP14195383.6

    申请日：2014-11-28

    申请人： Fundación Para El Fomento De La Investigación Sanitaria Y Biomédica De La Comunitat Valenciana

    发明人： Mira Obrador, Alejandro ,  Soro Áurea, Simón

    IPC分类号： G01N33/68 ,  G01N33/84

    CPC分类号： G01N33/6893 ,  G01N33/68 ,  G01N33/84 ,  G01N2800/18 ,  G01N2800/60

    摘要： The present invention discloses a method for predicting caries risk in a subject and a kit based on said method, characterized in that said method comprises:
    (a) determining the concentration in saliva from said subject of at least one compound selected from each of salivary components (i) of the immune system, (ii) involved in microbial adhesion to a surface of the buccal cavity; and (iii) involved in metabolism in the buccal cavity or in regulating the pH thereof;
    (b) comparing a response variable calculated from more than one concentration determined in step (a) with a corresponding reference response variable in a population of subjects without caries or in a population of subjects with caries; and
    (c) determining caries risk based on the degree of difference in response variable compared in step (b), wherein a greater degree of difference between the response variable of the subject and the corresponding reference response variable in a population of subjects without caries or in a population of subjects with caries, is indicative of higher caries risk in said subject.

    摘要翻译： 本发明公开了一种基于所述方法预测受试者和试剂盒的龋齿风险的方法，其特征在于所述方法包括：（a）确定所述受试者的唾液中至少一种选自唾液成分中的每种化合物的浓度 （i）免疫系统，（ii）涉及到颊腔表面的微生物粘附; 和（iii）参与颊腔中的代谢或调节其pH值; （b）将在步骤（a）中确定的多于一种浓度的反应变量与在不具有龋齿的受试者群体中的相应参考响应变量进行比较; 和（c）基于在步骤（b）中比较的响应变量的差异程度来确定龋齿风险，其中所述受试者的反应变量与没有龋齿的受试者群体中的相应参考响应变量之间的较大程度的差异 在具有龋齿的受试者群体中，表明所述受试者的龋齿风险较高。

    PRIMERS FOR THE DETECTION AND TYPING OF CARBAPENEMASE-PRODUCING BACTERIAL STRAINS, AND DETECTION METHOD AND KIT
    7.
    发明公开
    PRIMERS FOR THE DETECTION AND TYPING OF CARBAPENEMASE-PRODUCING BACTERIAL STRAINS, AND DETECTION METHOD AND KIT 有权
    引物检测和打字CARBAPENEMASEPRODUZIERENDEN株细菌及检测方法及试剂盒

    公开(公告)号：EP2940152A2

    公开(公告)日：2015-11-04

    申请号：EP14718156.4

    申请日：2014-02-28

    申请人： Fundación Para El Fomento De La Investigación Sanitaria Y Biomédica De La Comunitat Valenciana

    发明人： ROYO GARCÍA, Gloria ,  RODRÍGUEZ DÍAZ, Juan Carlos ,  GALIANA CABRERA, Antonio José

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/689 ,  C12Q2600/156 ,  C12Q2600/16

    摘要： Some pairs of primers are provided, being used for detection of carbapenemase genes and carbapenemase-producing bacterial strains, and a diagnosis method using said set of primers. Furthermore, there is also disclosed, preferably, the use of probes within each amplification reaction, more preferably multiplex PCR, for selective identification and detection of carbapenemase genes from a biological sample. The primers object of this invention may be used for preparing a kit for carbapenemase genes identification and detection, preferably carbapenemases contained in bacterial strains producing said enzymes.

    摘要翻译： 提供引物一些对，被用于检测碳青霉烯酶基因和碳青霉烯酶产生细菌菌株，以及使用所述引物组的诊断方法。 进一步，存在这样圆盘游离缺失，优选地，每个扩增反应中使用的探针，更优选为多重PCR用于选择性识别和碳青霉烯酶基因的检测从生物样品。 本发明的底漆对象可以用于制备用于碳青霉烯酶基因鉴定和检测的试剂盒，优选碳青霉烯中所含的细菌菌株产生所述酶。