发明公开
- 专利标题： MICE EXPRESSING AN IMMUNOGLOBULIN HYBRID LIGHT CHAIN
- 专利标题（中）： 表达免疫球蛋白混合轻链的小鼠
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申请号： EP16154526.4申请日： 2011-06-22
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公开(公告)号： EP3034608A1公开(公告)日： 2016-06-22
- 发明人: MACDONALD, Lynn , STEVENS, Sean , GURER, Cagan , MURPHY, Andrew J. , HOSIAWA, Karolina A.
- 申请人： REGENERON PHARMACEUTICALS, INC.
- 申请人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591 US
- 专利权人： REGENERON PHARMACEUTICALS, INC.
- 当前专利权人： REGENERON PHARMACEUTICALS, INC.
- 当前专利权人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591 US
- 代理机构： Power, David
- 优先权： US357317P 20100622; US357314P 20100622
- 主分类号： C12N15/85
- IPC分类号： C12N15/85 ; A01K67/027 ; C07K16/00 ; C07K16/46 ; C07K16/18 ; C12N15/10
摘要：
Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an episome wherein the hVλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided.
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