发明公开
- 专利标题： INHIBITORS OF HUMAN 12/15-LIPOXYGENASE
- 专利标题（中）： HUMAN一十五分之一十二脂氧合酶抑制剂的
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申请号： EP14837235.2申请日： 2014-08-22
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公开(公告)号： EP3036226A1公开(公告)日： 2016-06-29
- 发明人: VAN LEYEN, Klaus , HOLMAN, Theodore R. , MALONEY, David J. , JADHAV, Ajit , SIMEONOV, Anton , RAI, Ganesha
- 申请人： The General Hospital Corporation , The Regents of the University of California , The U.S.A. as represented by the Secretary, Department of Health and Human Services
- 申请人地址： 55 Fruit Street Boston, MA 02114 US
- 专利权人： The General Hospital Corporation,The Regents of the University of California,The U.S.A. as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The General Hospital Corporation,The Regents of the University of California,The U.S.A. as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： 55 Fruit Street Boston, MA 02114 US
- 代理机构： Kehoe, Laura Ellen
- 优先权： US201361868611P 20130822
- 国际公布： WO2015027146 20150226
- 主分类号： C07D263/48
- IPC分类号： C07D263/48 ; C07D277/42 ; C07D413/04 ; C07D417/04 ; A61K31/421 ; A61K31/422 ; A61K31/426 ; A61K31/427 ; A61K31/4709 ; A61K31/4725 ; A61P9/00 ; A61P9/10 ; A61P25/28 ; A61P35/00
摘要：
A systematic screening has revealed a family of compounds that exhibit inhibitory effects on 12/15-lipoxygenase. Accordingly, the present invention relates to the use of these compounds for the inhibition of 12/15-lipoxygenase and for the treatment of a condition involving 12/15-lipoxygenase. Exemplary conditions include, but are not limited to, stroke, periventricular leukomalacia, cardiac arrest with resuscitation, atherosclerosis, Parkinson's disease, Alzheimer's disease, and breast cancer.
公开/授权文献
- EP3036226B1 INHIBITORS OF HUMAN 12/15-LIPOXYGENASE 公开/授权日：2020-01-08
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