发明公开
EP3037554A1 METHODS FOR SELECTING COMPETENT OOCYTES AND COMPETENT EMBRYOS WITH HIGH POTENTIAL FOR PREGNANCY OUTCOME
有权
一种用于选择运算卵母细胞和胚胎运算具有高潜力的怀孕
- 专利标题： METHODS FOR SELECTING COMPETENT OOCYTES AND COMPETENT EMBRYOS WITH HIGH POTENTIAL FOR PREGNANCY OUTCOME
- 专利标题（中）： 一种用于选择运算卵母细胞和胚胎运算具有高潜力的怀孕
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申请号： EP16151156.3申请日： 2010-04-09
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公开(公告)号： EP3037554A1公开(公告)日： 2016-06-29
- 发明人: HAMAMAH, Samir , DE VOS, John , ASSOU, Said
- 申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , UNIVERSITE DE MONTPELLIER , Centre Hospitalier Universitaire de Montpellier
- 申请人地址： 101, rue de Tolbiac 75013 Paris FR
- 专利权人： INSERM (Institut National de la Santé et de la Recherche Médicale),UNIVERSITE DE MONTPELLIER,Centre Hospitalier Universitaire de Montpellier
- 当前专利权人： INSERM (Institut National de la Santé et de la Recherche Médicale),UNIVERSITE DE MONTPELLIER,Centre Hospitalier Universitaire de Montpellier
- 当前专利权人地址： 101, rue de Tolbiac 75013 Paris FR
- 代理机构： Cabinet Plasseraud
- 优先权： EP09305331 20090417; US175503P 20090505
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/68 ; G01N33/569
摘要：
The present invention relates to a method for selecting an oocyte that when fertilized produces a viable embryo with a high implantation rate leading to pregnancy by measuring, in a cumulus cell surrounding said oocyte, the expression level of 45 specific genes which consist in WNT6, LRCH4, PAX8, CABP4, PDE5A, BCL2L11, PCK1, TCF20, SLAMF6, EPOR, CACNG6, NLRP1, PECAM1, NOS1, ATF3, KRTAP8, GRIK5, SLC24A3, SLC5A12, SLCA10A2, SLCO1A2, SLC25A5, MG29, NLGN2, PRKACA, FOSB, SIAT6, LOXL2, PRF1, ADPRH, APBB3, EGR3, CNR2, IFITM1, PLA2G5, CAMTA1, SOX4, NFIB, NFIC, RBMS1, G0S2, FAT3, SLC40A1, GPC6 and IGF1R
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