A method for monitoring tire safety is adopted for use on a vehicle (1) which is equipped with a plurality of tires (2), a plurality of tire detection units (3) located respectively on each tire (2) to detect the interior conditions thereof, and an electronic device (4) which forms information link with each tire detection unit (3). The method includes: each tire detection unit (3) measures a corresponding tire measurement parameter; next, the tire measurement parameter is set in a tire status variation calculation formula and a contour variation calculation formula to calculate a plurality of parameters that represent each tire (2); next, calculate variation amounts of the parameters in an inspection time and convert to a status gradient data; then judge whether the status gradient data are coincided. Redo execution of the previous steps if the judged outcome is positive; otherwise generate an alarm signal about an abnormal condition through an electronic device (4) to alert the vehicle driver.