发明公开
EP3047275A1 COMPOSITIONS AND METHODS FOR INCREASING MESENCHYMAL STROMAL CELL MIGRATION TO TUMORS
审中-公开
组合物和方法增质STROMAZELLMIGRATION肿瘤
- 专利标题： COMPOSITIONS AND METHODS FOR INCREASING MESENCHYMAL STROMAL CELL MIGRATION TO TUMORS
- 专利标题（中）： 组合物和方法增质STROMAZELLMIGRATION肿瘤
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申请号： EP14842369.2申请日： 2014-09-05
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公开(公告)号： EP3047275A1公开(公告)日： 2016-07-27
- 发明人: MAZZOLINI, Guillermo Daniel , GARCIA, Mariana Gabriela , BAYO, Juan
- 申请人： Consejo Nacional De Investigaciones Cientificas Y Tecnicas , Asociación Civil De Estudios Superiores , Inis Biotech LLC
- 申请人地址： Rivadavia 1917 Ciudad Autonoma de Buenos Aires C1033AAJ AR
- 专利权人： Consejo Nacional De Investigaciones Cientificas Y Tecnicas,Asociación Civil De Estudios Superiores,Inis Biotech LLC
- 当前专利权人： Consejo Nacional De Investigaciones Cientificas Y Tecnicas,Asociación Civil De Estudios Superiores,Inis Biotech LLC
- 当前专利权人地址： Rivadavia 1917 Ciudad Autonoma de Buenos Aires C1033AAJ AR
- 代理机构： Miller, David James
- 优先权： US201361874852P 20130906
- 国际公布： WO2015035235 20150312
- 主分类号： G01N33/574
- IPC分类号： G01N33/574
摘要：
The present application is directed to compositions and methods for treating a subject with cancer and/or increasing migration of a mesenchymal stromal cells (MSCs) stimulated with a recombinant autocrine motility factor (rAMF) to a tumor or a tumor cell, e.g. hepatocellular carcinoma (HCC). In addition, methods for increasing adhesion of MSCs to endothelial cells with rAMF are disclosed. In some embodiments, the MSCs comprise a therapeutic agent, e.g., an anti-tumor agent.
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