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公开(公告)号：EP3364494A1
公开(公告)日：2018-08-22
申请号：EP16806280.0
申请日：2016-10-14
申请人： Consejo Nacional de Investigaciones Científicas Y Técnicas (CONICET) , Universidad Nacional De Cuyo , Inis Biotech LLC
CPC分类号： H01M10/54 , B09B3/00 , C22B1/005 , C22B3/165 , C22B7/007 , C22B23/0415 , C22B26/12 , Y02P10/234 , Y02W30/84
摘要： A method for the acid dissolution of LiCoO 2 contained in the cathode of lithium ion batteries, using acetic or tartaric acid as leaching agent, the method being characterized in that it comprises a first stage and a second stage, wherein said first stage comprises the step of separating the cathode components, while said second stage comprises the step of dissolving the pure LiCoO 2 with at least one acid. The method allows achieving an economically viable complete recycling process with low environmental impact.
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2.发明公开VACCINES FOR THE PREVENTION OF INFECTIONS WITH BORDETELLA 审中-公开IMPFSTOFFE ZURVERHÜTUNGVON INFEKTIONEN MIT BORDETELLA
公开(公告)号：EP2996714A1
公开(公告)日：2016-03-23
申请号：EP14722342.4
申请日：2014-03-25
申请人： Consejo Nacional de Investigaciones Científicas y Tecnicas (CONICET) , Universidade Nacional De La Plata , Inis Biotech LLC
发明人： HOZBOR, Daniela , BOTTERO, Daniela , GAILLARD, María Emilia , ZURITA, Eugenia , OMAZABAL, Maximiliano , FLORES, Darío , ERREA, Agustina , MORENO, Griselda , RUMBO, Martin , BARTEL, Erika , CASTUMA, Celina
IPC分类号： A61K39/00
CPC分类号： A61K39/099 , A61K39/0018 , A61K2039/545 , A61K2039/55505 , A61K2039/55544 , A61K2039/70
摘要： In another preferred embodiment, the vaccine for the prevention of infections with Bordetella comprises at least outer membrane vesicles (OMVs) of B. pertussis and the lipopolysaccharide of B. parapertussis, excipients and/or adjuvants. The vaccine can comprise between 3 to 20 μg per dose of OMVs from B. pertussis and between the amount equivalent to 107 and 1010 bacteria per dose of lipopolysaccharide of B. parapertussis. The adjuvant can be aluminum hydroxide and other immunogens such as tetanus toxoid, diphtheria toxoid, or combinations thereof. The Tdap vaccine exhibits cross activity.
摘要翻译： 在另一优选实施方案中，用于预防博德特氏菌感染的疫苗至少包含百日咳杆菌的外膜囊泡（OMV）和副百日咳杆菌的脂多糖，赋形剂和/或佐剂。 该疫苗可以包含3至20μg/剂量的来自百日咳百日日酵母的OMV，相当于每剂量百草枯副溶血素107至1010细菌的量。 佐剂可以是氢氧化铝和其它免疫原，例如破伤风类毒素，白喉类毒素或其组合。 Tdap疫苗显示交叉活性。
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3.发明授权DEVICE FOR DIAGNOSIS OF PHYSIOLOGIC STATUS AND/OR SELECTION OF THE BEST SPERMATOZOA OF A SEMEN SAMPLE BASED ON CHEMOTAXIS, AND PROCEDURE OF USE THEREOF 有权DEVICE生理状态和/或最佳的种子精子探头选择对CHEMO战术基本诊断和使用它们的方法
公开(公告)号：EP2403933B1
公开(公告)日：2015-05-06
申请号：EP10715593.9
申请日：2010-03-03
发明人： GIOJALAS, Laura Cecilia , GUIDOBALDI, Héctor Alejandro , GATICA, Laura Virginia , TEVES, María Eugenia , MONTESINOS, María del Mar , UÑATES, Diego Rafael
CPC分类号： G01N33/5091 , C12N5/061 , C12N5/0612 , C12N2501/39 , G01N33/5029 , G01N33/5088 , G01N2800/367
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公开(公告)号：EP2790707A1
公开(公告)日：2014-10-22
申请号：EP12819024.6
申请日：2012-12-14
发明人： RAMIREZ, Javier, Alberto , MICHELINI, Flavia, Mariana , GALAGOVSKY, Lydia, Raquel , BERRA, Alejandro , ALCHE, Laura, Edith
IPC分类号： A61K31/575 , A61P35/00
CPC分类号： C07J9/00 , A61K31/575 , A61K45/06
摘要： A method of treating a solid tumor in a mammal by inhibiting angiogenesis, comprising administering to the mammal which has a solid tumor selected from the group consisting of breast carcinoma, lung carcinoma, prostate carcinoma, colon carcinoma, ovarian carcinoma, neuroblastoma, central nervous system tumor, multiform glioblastoma and melanoma; a composition comprising brassinosteroids of general formula (I), wherein (I) can be a single or double bond and the configurations of carbon atoms C22 and C23 respectively linked to the substituents HO are S for both carbon atoms and a pharmaceutically acceptable additive.
摘要翻译： 通过抑制血管生成治疗哺乳动物中的实体瘤的方法，包括对具有选自乳腺癌，肺癌，前列腺癌，结肠癌，卵巢癌，成神经细胞瘤，中枢神经系统 肿瘤，多形性成胶质细胞瘤和黑素瘤; 包含通式（I）的油菜素类固醇的组合物，其中（I）可以是单键或双键，并且分别与取代基HO连接的碳原子C22和C23的构型对于两个碳原子都是S和药学上可接受的添加剂。
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5.发明公开METHOD FOR THE IDENTIFICATION OF GENES INVOLVED IN NEURODEGENERATIVE PROCESSES 审中-公开方法鉴定神经退行性过程相关的基因
公开(公告)号：EP2329026A2
公开(公告)日：2011-06-08
申请号：EP09809411.3
申请日：2009-08-20
申请人： Inis Biotech LLC , Fundacion Instituto Leloir , Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet)
CPC分类号： C07K14/43581
摘要： A method for the identification of genes involved in neurodegenerative processes, detectable by the late onset of a phenotype associated with neurodegeneration, by means of a genetic screen of deregulated genes, which comprises the measurement of sleep-wake cycle activity schemes in different stages of life, young and adult, of individuals of an animal model, such as Drosophila. A mutant fly whose genome comprises a disruption in its enabled gene, with decrease of the enabled gene expression, and exhibiting a late onset neurodegenerative phenotype in adulthood.
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公开(公告)号：EP2087286A2
公开(公告)日：2009-08-12
申请号：EP07849119.8
申请日：2007-11-13
IPC分类号： F23L17/04
CPC分类号： F23L17/04 , F24H9/0084
摘要： A passive stream regulating system applicable to air-flue gas or water-flue gas heat exchangers, preferably natural gas balanced flue or natural flue home heaters and home boilers, which allows to attain non-over oxygenated stoichiometric mixture conditions. The system is comprised by small diameter tubes or other geometric systems formed by small channels, to produce a strong laminarization of the aerodynamic flow established within the venting tube, which are located in sections of the conduit or passage of incoming cold air to the combustion chamber of the exchanger or in sections of the conduit or passage of hot flue gases released to the environment.
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公开(公告)号：EP2809787B8
公开(公告)日：2018-11-28
申请号：EP13743957.6
申请日：2013-02-01
申请人： Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET) , Universidad Nacional del Litoral , Inis Biotech LLC , Chan, Raquel Lia , Cabello, Julieta Virginia , Giacomelli, Jorge Ignacio
CPC分类号： C12N15/8273 , C07K14/415 , C12N15/8261 , C12N15/8271 , Y02A40/146
摘要： The present invention provides isolated HaHB11 polypeptides and nucleic acids encoding the same. Also provided are methods of introducing a nucleic acid encoding HaHB11 polypeptides into a plant cell, plant part or plant, e.g., to increase tolerance to abiotic stress, to delay development and/or prolong the life span of a plant, and/or to increase yield from the plant. The invention also provides nucleic acids comprising HaHB11 promoter sequences and methods for expressing a nucleotide sequence of interest operably associated with the HaHB11 promoters of the invention in a plant cell, plant part, or plant. Also provided are transformed plants, plant tissues, plant cells and plant seed comprising the nucleic acids, expression cassettes and vectors of the invention.
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8.发明授权A COMPOUND SHOWING ANTI-INFLAMMATORY ACTIVITY AND ANTIVIRAL ACTIVITY, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, A PROCESS FOR OBTAINING THE SAME AND USE OF THE SAME IN THE TREATMENT OF EPIDEMIC KERATOCONJUNCTIVITES AND HERPETIC STROMAL KERATIS 有权具有抗炎和抗病毒的作用，药物组合物时，提取工艺和使用节点在流行性角膜结膜炎和间质疱疹性角膜炎的治疗
公开(公告)号：EP2178898B1
公开(公告)日：2016-02-24
申请号：EP08789194.1
申请日：2008-07-04
发明人： RAMIREZ, Javier Alberto , MICHELINI, Flavia Mariana , GALAGOVSKY, Lydia Raquel , BERRA, Alejandro , ALCHE, Laura Edith
IPC分类号： C07J9/00
CPC分类号： C07J9/00
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9.发明公开
公开(公告)号：EP2809787A1
公开(公告)日：2014-12-10
申请号：EP13743957.6
申请日：2013-02-01
申请人： CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TÉCNICAS (CONICET) , Unl - Universidad Nacional Del Litoral , Inis Biotech LLC , Chan, Raquel Lia , Cabello, Julieta Virginia , Giacomelli, Jorge Ignacio
CPC分类号： C12N15/8273 , C07K14/415 , C12N15/8261 , C12N15/8271 , Y02A40/146
摘要： The present invention provides isolated HaHB11 polypeptides and nucleic acids encoding the same. Also provided are methods of introducing a nucleic acid encoding HaHB11 polypeptides into a plant cell, plant part or plant, e.g., to increase tolerance to abiotic stress, to delay development and/or prolong the life span of a plant, and/or to increase yield from the plant. The invention also provides nucleic acids comprising HaHB11 promoter sequences and methods for expressing a nucleotide sequence of interest operably associated with the HaHB11 promoters of the invention in a plant cell, plant part, or plant. Also provided are transformed plants, plant tissues, plant cells and plant seed comprising the nucleic acids, expression cassettes and vectors of the invention.
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公开(公告)号：EP2048954B1
公开(公告)日：2012-03-28
申请号：EP07776311.8
申请日：2007-04-26
申请人： Inis Biotech LLC , Inis Biotech SA
发明人： PODHAJCER, Osvaldo, Luis , CAFFERATA, Eduardo, Gustavo, Alfredo , LOPEZ, Maria, Veronica , VIALE, Diego, Luis
CPC分类号： C07K14/4748
摘要： An isolated DNA sequence corresponding to a region of the SPARC gene human promoter from base pair -513 to base pair +3 5 capable of driving the expression of a heterologous gene of interest, that can be associated to any other promoter sequence, such as radiation responsive sequence, hypoxia responsive sequence and free-radical responsive sequence. The invention also provides constructs and DNA recombinant expression viral vectors, comprising said isolated sequence of the SPARC gene human promoter and at least one heterologous gene operably linked thereto, wherein said promoter sequence drives the expression of the at least one heterologous gene in tumor cells. Pharmaceutical compositions and a method for treating tumors are also provided.
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