发明公开
EP3052516A1 PCV2 ORF2 PROTEIN VARIANT AND VIRUS LIKE PARTICLES COMPOSED THEREOF
审中-公开
PCV2-ORF2-PROTEINVARIANTE UNDVIRUSÄHNLICHENPARTIKEL DARAUS
- 专利标题： PCV2 ORF2 PROTEIN VARIANT AND VIRUS LIKE PARTICLES COMPOSED THEREOF
- 专利标题（中）： PCV2-ORF2-PROTEINVARIANTE UNDVIRUSÄHNLICHENPARTIKEL DARAUS
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申请号： EP14789683.1申请日： 2014-10-02
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公开(公告)号： EP3052516A1公开(公告)日： 2016-08-10
- 发明人: HERNANDEZ, Luis Alejandro , MUEHLENTHALER, Christine Margaret , VAUGHN, Eric Martin , HAIWICK, Gregory
- 申请人： Boehringer Ingelheim Vetmedica, Inc.
- 申请人地址： 2621 North Belt Highway St. Joseph, MO 64506 US
- 专利权人： Boehringer Ingelheim Vetmedica, Inc.
- 当前专利权人： Boehringer Ingelheim Vetmedica, Inc.
- 当前专利权人地址： 2621 North Belt Highway St. Joseph, MO 64506 US
- 代理机构： Simon, Elke Anna Maria
- 优先权： US201361885871P 20131002
- 国际公布： WO2015051099 20150409
- 主分类号： C07K14/005
- IPC分类号： C07K14/005 ; C12N7/04 ; A61K39/12
摘要：
Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.
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