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    PCV2 ORF2 PROTEIN VARIANT AND VIRUS LIKE PARTICLES COMPOSED THEREOF
    1.
    发明公开
    PCV2 ORF2 PROTEIN VARIANT AND VIRUS LIKE PARTICLES COMPOSED THEREOF 审中-公开
    PCV2-ORF2-PROTEINVARIANTE UNDVIRUSÄHNLICHENPARTIKEL DARAUS

    公开(公告)号：EP3052516A1

    公开(公告)日：2016-08-10

    申请号：EP14789683.1

    申请日：2014-10-02

    申请人： Boehringer Ingelheim Vetmedica, Inc.

    发明人： HERNANDEZ, Luis Alejandro ,  MUEHLENTHALER, Christine Margaret ,  VAUGHN, Eric Martin ,  HAIWICK, Gregory

    IPC分类号： C07K14/005 ,  C12N7/04 ,  A61K39/12

    摘要： Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.

    摘要翻译： 公开了用不同PCV2亚型控制PCV2感染的疫苗接种方法。 具体地说，在用于治疗或预防相同PCV2b和/或不同亚型的PCV2的感染的方法中使用包含PCV2b ORF2蛋白的PCV2亚型b（PCV2b）ORF2蛋白或免疫原性组合物; 减少，预防或治疗由相同PCV2b或不同亚型的PCV2感染引起的临床体征; 和/或预防或治疗由相同PCV2b和/或不同亚型的PCV2感染引起的疾病。 本发明特别涉及PCV2亚型b（PCV2b）ORF2蛋白，其特征在于它们在BC环中含有至少一个突变，使得与PCV2不相似的PCV2 ORF2蛋白相比，表达的蛋白优选以更高的量表达 含有这种突变。