发明公开
- 专利标题： METHODS FOR ASSESSING LIVER TOXICITY
- 专利标题（中）： 评估肝毒性的方法
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申请号： EP16158939.5申请日： 2009-05-26
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公开(公告)号： EP3059592A1公开(公告)日： 2016-08-24
- 发明人: VAN RAVENZWAAY, Bennard , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , FABIAN, Eric , STRAUSS, Volker , KAMP, Hennicke , WALK, Tilmann B. , LOOSER, Ralf , HEROLD, Michael Manfred , WIEMER, Jan C. , PROKOUDINE, Alexandre , LEIBOLD, Edgar
- 申请人： BASF SE
- 申请人地址： Carl-Bosch-Strasse 38 67056 Ludwigshafen am Rhein DE
- 专利权人： BASF SE
- 当前专利权人： BASF SE
- 当前专利权人地址： Carl-Bosch-Strasse 38 67056 Ludwigshafen am Rhein DE
- 代理机构： Herzog, Fiesser & Partner Patentanwälte PartG mbB
- 优先权： EP08157117 20080528; EP09151548 20090128
- 主分类号： G01N33/66
- IPC分类号： G01N33/66 ; G01N33/92
摘要：
The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject.
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