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6 条记录 (耗时 0.018 秒)

    METHODS FOR ASSESSING LIVER TOXICITY
    3.
    发明公开
    METHODS FOR ASSESSING LIVER TOXICITY 审中-公开
    评估肝毒性的方法

    公开(公告)号：EP3059592A1

    公开(公告)日：2016-08-24

    申请号：EP16158939.5

    申请日：2009-05-26

    申请人： BASF SE

    发明人： VAN RAVENZWAAY, Bennard ,  MELLERT, Werner ,  COELHO PALERMO CUNHA, Georgia ,  FABIAN, Eric ,  STRAUSS, Volker ,  KAMP, Hennicke ,  WALK, Tilmann B. ,  LOOSER, Ralf ,  HEROLD, Michael Manfred ,  WIEMER, Jan C. ,  PROKOUDINE, Alexandre ,  LEIBOLD, Edgar

    IPC分类号： G01N33/66 ,  G01N33/92

    CPC分类号： G01N33/92 ,  G01N2500/00 ,  G01N2560/00 ,  G01N2800/085 ,  G01N2800/60 ,  Y02A90/26

    摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject.

    摘要翻译： 本发明涉及用于化合物风险分层的毒理学评估领域。 具体而言，涉及诊断肝毒性的方法。 本发明还涉及确定化合物是否能够在受试者中诱导这种肝毒性的方法以及鉴定用于治疗肝毒性的药物的方法。 此外，本发明涉及包含至少五种代谢物的特征值的数据收集物，包含所述数据收集物的数据存储介质以及用于诊断肝毒性的系统和装置。 最后，本发明涉及一组代谢物或用于确定其用于制造用于诊断受试者的肝毒性的诊断装置或组合物的手段的用途。

    A METHOD FOR PROVIDING AND ANALYZING AN ANIMAL POPULATION HAVING AN ESSENTIALLY IDENTICAL METABOLOME
    6.
    发明公开
    A METHOD FOR PROVIDING AND ANALYZING AN ANIMAL POPULATION HAVING AN ESSENTIALLY IDENTICAL METABOLOME 有权
    方法提供和动物种群具有相同的实质性代谢分析

    公开(公告)号：EP1909561A1

    公开(公告)日：2008-04-16

    申请号：EP06777668.2

    申请日：2006-07-10

    申请人： BASF SE

    发明人： RAVENZWAAY, Bennard van ,  COELHO PALERMO CUNHA, Georgia ,  MELLERT, Werner ,  LOOSER, Ralf ,  WALK, Tilmann B. ,  WIEMER, Jan C. ,  HAAKE, Volker

    IPC分类号： A01K29/00 ,  A01K1/03 ,  A01K67/02

    CPC分类号： A01K1/031 ,  A01K29/00 ,  A01K67/02

    摘要： The present invention relates to a method for providing an animal population having an essentially identical metabolome comprising compiling an animal population being of essentially the same age, keeping said animal population for a time period sufficient for acclimatization under the following housing conditions: (i) constant temperature, (ii) constant humidity, (iii) physical separation of the animals of the animal population, (iv) feeding ad libitum, wherein the food to be fed is essentially free of chemical or micro- bial contaminance, (v) drinking libitum, wherein the drinking liquid is essentially free of chemical or microbial contaminance, (vi) constant illumination period, and providing the animal population after said time period. Further, the present invention relates to methods for the identification of a compound which effects the metabolome of an animal, or methods for the identification of a marker for such compounds. Moreover, the present invention encompasses methods for the identification of such compounds or markers thereof comprising metabolically analyzing a sample from at least one animal of an animal population.