发明公开
- 专利标题: ANTIDIABETIC TRICYCLIC COMPOUNDS
- 专利标题(中): ANTIDIABETISCHE TRICYCLISCHE VERBINDUNGEN
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申请号: EP14862098申请日: 2014-11-10
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公开(公告)号: EP3068768A4公开(公告)日: 2017-04-05
- 发明人: BIFTU TESFAYE , BIJU PURAKKATTLE , COLLETTI STEVEN L , DANG QUN , DHONDI PAWAN K , GUDE CANDIDO , JOSIEN HUBERT , KAR NAM FUNG , NAIR ANILKUMAR G , NARGUND RAVI P , YANG DE-YI , XIAO DONG , ZHU CHENG
- 申请人: MERCK SHARP & DOHME
- 专利权人: MERCK SHARP & DOHME
- 当前专利权人: MERCK SHARP & DOHME
- 优先权: US201361904673 2013-11-15; US201462042442 2014-08-27
- 主分类号: C07D221/16
- IPC分类号: C07D221/16 ; A61K31/435 ; A61P3/10 ; C07D401/12 ; C07D487/04 ; C07D487/10
摘要:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
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