发明公开
EP3071203A2 TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
审中-公开
四氢喹喔啉组合物作为BET金属溴化物抑制剂
- 专利标题： TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
- 专利标题（中）： 四氢喹喔啉组合物作为BET金属溴化物抑制剂
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申请号： EP14862604.7申请日： 2014-11-18
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公开(公告)号： EP3071203A2公开(公告)日： 2016-09-28
- 发明人: Bair, Kenneth W. , Herbertz, Torsten , Kauffman, Goss Stryker , Kayser-Bricker, Katherine J. , Luke, George P. , Martin, Matthew W. , Millan, David S. , Schiller, Shawn E.R. , Talbot, Adam C.
- 申请人： Forma Therapeutics, Inc.
- 申请人地址： 500 Arsenal St., Suite 100 Watertown, MA 02472 US
- 专利权人： Forma Therapeutics, Inc.
- 当前专利权人： Forma Therapeutics, Inc.
- 当前专利权人地址： 500 Arsenal St., Suite 100 Watertown, MA 02472 US
- 代理机构： Grund, Martin
- 优先权： US201361905639P 20131118; US201462054811P 20140924
- 国际公布： WO2015074064 20150521
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; A61K31/4709 ; C07D401/02
摘要：
The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein W, X, Y, Z, R
1 , R
2 , R
5 , and R
8 are as described herein.
1 , R
2 , R
5 , and R
8 are as described herein.
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