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公开(公告)号：EP3472131B1
公开(公告)日：2020-02-19
申请号：EP17735280.4
申请日：2017-06-16
IPC分类号： C07D209/54 , C07D401/04 , C07D401/06 , C07D221/20 , A61P35/00 , A61K31/403 , A61K31/4747 , A61K31/4439 , A61K31/444 , A61P29/00 , A61P25/00
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公开(公告)号：EP3414251B1
公开(公告)日：2019-10-16
申请号：EP17706132.2
申请日：2017-02-13
发明人： GUERIN, David Joseph , BAIR, Kenneth W. , CARAVELLA, Justin A. , IOANNIDIS, Stephanos , LANCIA, JR., David R. , LI, Hongbin , MISCHKE, Steven , NG, Pui Yee , RICHARD, David , SCHILLER, Shawn E.R. , SHELEKHIN, Tatiana , WANG, Zhongguo
IPC分类号： C07D495/04 , A61K31/4985 , A61P35/00 , A61P37/00
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3.发明公开3-ARYL-4-AMIDO-BICYCLIC [4,5,0]HYDROXAMIC ACIDS AS HDAC INHIBITORS 审中-公开作为HDAC抑制剂的3-芳基-4-氨基 - 二环[4,5,0]羟基酸
公开(公告)号：EP3292116A1
公开(公告)日：2018-03-14
申请号：EP16704357.9
申请日：2016-02-02
发明人： ZHENG, Xiaozhang , NG, Pui Yee , HAN, Bingsong , THOMASON, Jennifer R. , ZABLOCKI, Mary-Margaret , LIU, Cuixian , DAVIS, Heather , RUDNITSKAYA, Aleksandra , LANCIA, David, Jr. , MILLAN, David S. , MARTIN, Matthew W.
IPC分类号： C07D403/06 , C07D413/06 , C07D243/14 , C07D267/12 , A61K31/551 , A61K31/553 , A61P35/00
CPC分类号： C07D267/14 , C07D243/14 , C07D267/12 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/04 , C07D413/06 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/107 , C07D493/08 , C07D495/10 , C07D498/04 , C07D498/08
摘要： The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
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4.发明公开PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS 审中-公开吡啶-2（1H）酮喹啉酮衍生物作为突变体 - 离心脱氢酶抑制剂
公开(公告)号：EP3194376A1
公开(公告)日：2017-07-26
申请号：EP15778433.1
申请日：2015-09-18
发明人： ASHWELL, Susan , CAMPBELL, Ann-Marie , CARAVELLA, Justin Andrew , DIEBOLD, R. Bruce , ERICSSON, Anna , GUSTAFSON, Gary , LANCIA, David R. , LIN, Jian , LU, Wei , WANG, Zhongguo
IPC分类号： C07D401/12 , A61P35/00 , A61K31/4704 , A61K31/4709 , C07D471/04 , C07D401/14
CPC分类号： C07D401/12 , A61K31/47 , C07D401/14 , C07D471/04
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
摘要翻译： 其中A，U，W1，W2，W3，R1-R6和R9在本文中描述。
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5.发明公开PHENYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS 有权苯基喹啉酮衍生物作为突变 - 脱碳酸脱氢酶抑制剂
公开(公告)号：EP3194375A1
公开(公告)日：2017-07-26
申请号：EP15771464.3
申请日：2015-09-18
发明人： ASHWELL, Susan , CAMPBELL, Ann-Marie , CARAVELLA, Justin Andrew , DIEBOLD, R. Bruce , ERICSSON, Anna , GUSTAFSON, Gary , LANCIA, David R. , LIN, Jian , LU, Wei , WANG, Zhongguo
IPC分类号： C07D401/12 , A61P35/00 , A61K31/4704 , A61K31/4709 , C07D215/227 , C07D471/04 , C07D405/12 , C07D409/12
CPC分类号： C07D215/227 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R8 are described herein.
摘要翻译： 本发明涉及用于治疗细胞增殖性疾病和癌症的具有新形态活性的突变异柠檬酸脱氢酶（mt-IDH）蛋白的抑制剂，其具有下式：其中A，B，W 1，W 2，W 3和R 1 -R 8是 在此描述。
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公开(公告)号：EP3071205A1
公开(公告)日：2016-09-28
申请号：EP14862659.1
申请日：2014-11-18
发明人： BAIR, Kenneth, W. , HERBERTZ, Torsten , KAUFFMAN, Goss, Stryker , KAYSER-BRICKER, Katherine, J. , LUKE, George, P. , MARTIN, Matthew, W. , MILLAN, David, S. , SCHILLER, Shawn, E. R. , TALBOT, Adam, C. , TEBBE, Mark, J.
IPC分类号： A61K31/53 , A61K31/4985 , C07D487/04
摘要： wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.
摘要翻译： 本发明涉及可用于治疗癌症，炎症性疾病，糖尿病和肥胖症的具有式（I）的溴和额外末端（BET）溴结构域的抑制剂：其中X，Y，Z，R 1，R 2 ，R 4和R 7在本文中定义。
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公开(公告)号：EP3071203A2
公开(公告)日：2016-09-28
申请号：EP14862604.7
申请日：2014-11-18
发明人： Bair, Kenneth W. , Herbertz, Torsten , Kauffman, Goss Stryker , Kayser-Bricker, Katherine J. , Luke, George P. , Martin, Matthew W. , Millan, David S. , Schiller, Shawn E.R. , Talbot, Adam C.
IPC分类号： A61K31/47 , A61K31/4709 , C07D401/02
CPC分类号： C07D487/04 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D215/20 , C07D215/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D473/28 , A61K2300/00
摘要： The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein W, X, Y, Z, R
1 , R
2 , R
5 , and R
8 are as described herein.摘要翻译： 本发明涉及用于治疗癌症，炎性疾病，糖尿病和肥胖症的式（I）的溴和额外末端（BET）溴结构域的抑制剂：其中W，X，Y，Z，R 1， R 2，R 5和R 8如本文所述。
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公开(公告)号：EP2968316A1
公开(公告)日：2016-01-20
申请号：EP14779048.9
申请日：2014-03-11
发明人： BAIR, Kenneth, W. , LANCIA, David, R. , LI, Hongbin , LOCH, James , LU, Wei , MARTIN, Matthew, W. , MILLAN, David, S. , SCHILLER, Shawn, E.r. , TEBBE, Mark, J.
IPC分类号： A61K31/4965
CPC分类号： C07D295/192 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K45/06 , C07D209/08 , C07D209/18 , C07D213/56 , C07D213/65 , C07D213/69 , C07D215/14 , C07D217/16 , C07D231/12 , C07D231/56 , C07D235/08 , C07D257/04 , C07D263/57 , C07D271/12 , C07D277/62 , C07D277/66 , C07D305/08 , C07D401/04 , C07D403/04 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D513/04 , A61K2300/00
摘要： The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
摘要翻译： 本发明涉及用于抑制FASN的化合物和组合物，它们的合成，应用和解毒剂。 下面显示了本发明的说明性化合物：
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公开(公告)号：EP3793997B1
公开(公告)日：2024-03-13
申请号：EP19728257.7
申请日：2019-05-16
IPC分类号： C07D471/04 , C07D487/04 , A61P25/28 , A61K31/4985
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公开(公告)号：EP3636637A1
公开(公告)日：2020-04-15
申请号：EP19202580.7
申请日：2019-10-10
发明人： Martin, Matthew W. , Zablocki, Mary-Margaret , Mente, Scot , Dinsmore, Christopher , Wang, Zhongguo , Zheng, Xiaozhang
IPC分类号： C07D221/20 , C07D401/06 , C07D401/10 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/10 , C07D413/14 , A61P1/16 , A61K31/438
摘要： The present disclosure is directed to inhibitors of FASN. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of FASN. For instance, the disclosure is concerned with compounds and compositions for inhibition of FASN, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of FASN, and methods of synthesis of these compounds.
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