发明公开
EP3080114A1 FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY
审中-公开
稠合三环IMIDAZOLENDERIVATE AS TNF活性的调节
- 专利标题： FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY
- 专利标题（中）： 稠合三环IMIDAZOLENDERIVATE AS TNF活性的调节
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申请号： EP14808659.8申请日： 2014-12-08
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公开(公告)号： EP3080114A1公开(公告)日： 2016-10-19
- 发明人: ALEXANDER, Rikki Peter , BROWN, Julien Alistair , DELIGNY, Michael , HEER, Jag Paul , JACKSON, Victoria Elizabeth , JADOT, Sophie , KROEPLIEN, Boris , MAC COSS, Malcolm , SABNIS, Yogesh Anil , SWINNEN, Dominique Louis Léon , VAN HOUTVIN, Nathalie , ZHU, Zhaoning
- 申请人： UCB Biopharma SPRL
- 申请人地址： Allée de la Recherche 60 1070 Brussels BE
- 专利权人： UCB Biopharma SPRL
- 当前专利权人： UCB Biopharma SPRL
- 当前专利权人地址： Allée de la Recherche 60 1070 Brussels BE
- 代理机构： Duckworth, Timothy John
- 优先权： GB201321730 20131209
- 国际公布： WO2015086527 20150618
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437 ; A61K31/4375 ; C07D471/14 ; C07D491/14
摘要：
A series of substituted fused tricyclic imidazole derivatives, in particular dihydro-1H-pyrano[4′,3′:4,5]imidazo[1,2-a]pyridine, 1,2,3,4-tetrahydroimidazo[1,2-a:5,4-c′]dipyridine, dihydro-1H-pyrano[3′,4′:4,5]imidazo[1,2-a]pyridine and tetrahydro-6H-cyclohepta[4,5]imidazo[1,2-a]pyridine, and analogs thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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