公开(公告)号：EP3080120B1

公开(公告)日：2019-06-19

申请号：EP14812175.9

申请日：2014-12-08

申请人： UCB Biopharma SPRL

发明人： BROWN, Julien Alistair ,  CALMIANO, Mark Daniel ,  JONES, Elizabeth Pearl ,  KROEPLIEN, Boris ,  REUBERSON, James Thomas ,  SELBY, Matthew Duncan ,  SHAW, Michael Alan ,  ZHU, Zhaoning

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P29/00

公开(公告)号：EP3311169A1

公开(公告)日：2018-04-25

申请号：EP15784069.5

申请日：2015-10-22

申请人： UCB Biopharma SPRL

发明人： O'CONNELL, James Philip ,  PORTER, John Robert ,  LAWSON, Alastair ,  KROEPLIEN, Boris ,  RAPECKI, Stephen Edward ,  NORMAN, Timothy John ,  WARRELLOW, Graham John

IPC分类号： G01N33/68 ,  C07D401/14 ,  C07K14/525 ,  C07D471/00 ,  C07K14/705

CPC分类号： G01N33/6845 ,  A61K47/6425 ,  A61P35/00 ,  A61P37/00 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D401/14 ,  C07D471/00 ,  C07D471/04 ,  C07K14/525 ,  C07K14/70575 ,  C07K16/241 ,  C07K2317/55 ,  C07K2317/92 ,  G01N33/6854 ,  G01N33/6863 ,  G01N2333/525 ,  G01N2500/02

摘要： The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

公开(公告)号：EP2858983B1

公开(公告)日：2018-04-18

申请号：EP13727932.9

申请日：2013-06-11

申请人： UCB Biopharma SPRL

发明人： BROOKINGS, Daniel, Christopher ,  CALMIANO, Mark, Daniel ,  GALLIMORE, Ellen, Olivia ,  HORSLEY, Helen, Tracey ,  HUTCHINGS, Martin, Clive ,  JOHNSON, James, Andrew ,  KROEPLIEN, Boris ,  LECOMTE, Fabien, Claude ,  LOWE, Martin, Alexander ,  NORMAN, Timothy, John ,  PORTER, John, Robert ,  QUINCEY, Joanna, Rachel ,  REUBERSON, James, Thomas ,  SELBY, Matthew, Duncan ,  SHAW, Michael, Alan ,  ZHU, Zhaoning ,  FOLEY, Anne Marie

IPC分类号： C07D401/04 ,  C07D235/12 ,  A61K31/4427 ,  A61P29/00

CPC分类号： C07D235/12 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/06 ,  C07D491/107

摘要： A series of benzimidazole derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：EP3080118A1

公开(公告)日：2016-10-19

申请号：EP14811826.8

申请日：2014-12-08

申请人： UCB Biopharma SPRL

发明人： JACKSON, Victoria Elizabeth ,  KROEPLIEN, Boris ,  LOWE, Martin Alexander ,  PORTER, John Robert

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P29/00 ,  A61P37/00

摘要： A series of substituted 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine derivatives, being potent treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

摘要翻译： 一系列取代的4,5,6,7-四氢-1H-咪唑并[4,5-c]吡啶衍生物，是有效治疗和/或预防各种人类疾病，包括自身免疫和炎性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱; 眼部疾病; 和肿瘤疾病。

公开(公告)号：EP3080110A1

公开(公告)日：2016-10-19

申请号：EP14808639.0

申请日：2014-12-08

申请人： UCB Biopharma SPRL

发明人： DEFAYS, Sabine ,  HEER, Jag Paul ,  JACKSON, Victoria Elizabeth ,  JOHNSON, James Andrew ,  KROEPLIEN, Boris ,  PORTER, John Robert

IPC分类号： C07D471/04 ,  A61K31/425

CPC分类号： C07D471/04 ,  A61K31/4184 ,  A61K31/437 ,  A61K2300/00

摘要： A series of substituted 5,6,7,8-tetrahydroimidazo[1,2-α]pyridine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

摘要翻译： 一系列作为人TNFα活性的有效调节剂的取代的5,6,7,8-四氢咪唑并[1,2-a]吡啶衍生物相应地在治疗和/或预防各种人类疾病中是有益的，所述人类疾病包括自身免疫和 炎性疾病; 神经和神经退行性疾病; 疼痛和伤害性疼痛; 心血管疾病; 代谢紊乱; 眼病; 和肿瘤疾病。

公开(公告)号：EP3080115B1

公开(公告)日：2019-05-08

申请号：EP14809624.1

申请日：2014-12-08

申请人： UCB Biopharma SPRL

发明人： ALEXANDER, Rikki Peter ,  BENTLEY, Jonathan Mark ,  BRACE, Gareth Neil ,  BROOKINGS, Daniel Christopher ,  CHOVATIA, Praful Tulshi ,  DEBOVES, Hervé Jean Claude ,  JOHNSTONE, Craig ,  JONES, Elizabeth Pearl ,  KROEPLIEN, Boris ,  LECOMTE, Fabien Claude ,  MADDEN, James ,  MILLER, Craig Adrian ,  PORTER, John Robert ,  SELBY, Matthew Duncan ,  SHAW, Michael Alan ,  VAIDYA, Darshan Gunvant ,  YULE, Ian Andrew

IPC分类号： C07D471/04 ,  A61K31/437 ,  C07D519/00 ,  A61P37/00 ,  A61P43/00

公开(公告)号：EP3303318A1

公开(公告)日：2018-04-11

申请号：EP16728291.2

申请日：2016-06-07

申请人： UCB Biopharma SPRL

发明人： BRACE, Gareth Neil ,  CHOVATIA, Prafulkumar Tulshibhai ,  FOULKES, Gregory ,  JOHNSON, James Andrew ,  JONES, Severine Danielle ,  KROEPLIEN, Boris ,  LECOMTE, Fabien Claude ,  LOKE, Pui Leng ,  LOWE, Martin Alexander ,  MANDAL, Ajay ,  NORMAN, Timothy John ,  PALMER, Christopher Francis ,  PÉREZ-FUERTES, Yolanda ,  PORTER, John Robert ,  SMYTH, Donald ,  TRANI, Giancarlo ,  UDDIN, Muhammed ,  ZHU, Zhaoning

IPC分类号： C07D401/06 ,  C07D413/06 ,  C07D498/04 ,  A61K31/517 ,  A61K31/519 ,  A61P29/00

CPC分类号： C07D498/04 ,  A61K31/423 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/473 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/55 ,  A61P3/00 ,  A61P9/00 ,  A61P23/00 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  C07D401/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D519/00

摘要： A series of substituted 3,4-dihydro-2H-.1,4-benzoxazin-3-one derivatives, and analogues thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neuradegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：EP3080128A1

公开(公告)日：2016-10-19

申请号：EP14808641.6

申请日：2014-12-08

申请人： UCB Biopharma SPRL

发明人： ALI, Mezher Hussein ,  BROOKINGS, Daniel Christopher ,  BROWN, Julien Alistair ,  HUTCHINGS, Martin Clive ,  JACKSON, Victoria Elizabeth ,  KROEPLIEN, Boris ,  PORTER, John Robert ,  QUINCEY, Joanna Rachel

IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P29/00

摘要： A series of substituted imidazo[1,2-b]pyridazine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

摘要翻译： 因此，作为人类TNFα活性的有效调节剂的一系列取代的式（I）咪唑并[1,2-b]哒嗪衍生物因此有益于治疗和/或预防各种人类疾病，包括自身免疫和炎性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱; 眼部疾病; 和肿瘤疾病。

公开(公告)号：EP3080117A1

公开(公告)日：2016-10-19

申请号：EP14811823.5

申请日：2014-12-08

申请人： UCB Biopharma SPRL

发明人： JACKSON, Victoria Elizabeth ,  KROEPLIEN, Boris ,  PORTER, John Robert

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P29/00

摘要： A series of substituted 3H-imidazo[4,5-c]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：EP3080091A1

公开(公告)日：2016-10-19

申请号：EP14808650.7

申请日：2014-12-08

申请人： UCB Biopharma SPRL

发明人： HEER, Jag Paul ,  JACKSON, Victoria Elizabeth ,  KROEPLIEN, Boris ,  LECOMTE, Fabien Claude ,  PORTER, John Robert

IPC分类号： C07D235/12 ,  A61K31/4184 ,  A61P29/00

CPC分类号： C07D401/10 ,  A61K31/4439 ,  C07D235/12

摘要： A series of substituted 4,5,6,7-tetrahydrobenzimidazole derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

摘要翻译： 一系列取代的4,5,6,7-四氢苯并咪唑衍生物是人TNFα活性的有效调节剂，因此在治疗和/或预防各种人类疾病中是有益的，所述人类疾病包括自身免疫性和炎症性疾病; 神经和神经退行性疾病; 疼痛和伤害性疼痛; 心血管疾病; 代谢紊乱; 眼病; 和肿瘤疾病。