发明公开
EP3083592A2 SUBSTITUIERTE PIPERIDINYL-TETRAHYDROCHINOLINE UND IHRE VERWENDUNG ALS ALPHA-2C ADRENOREZEPTOR ANTAGONISTEN
有权
被哌啶基，四氢喹啉及其作为ALPHA-2C阻断拮抗剂
- 专利标题： SUBSTITUIERTE PIPERIDINYL-TETRAHYDROCHINOLINE UND IHRE VERWENDUNG ALS ALPHA-2C ADRENOREZEPTOR ANTAGONISTEN
- 专利标题（英）： Substituted piperidinyl-tetrahydroquinolines and their use as alpha-2c adrenoreceptor antagonists
- 专利标题（中）： 被哌啶基，四氢喹啉及其作为ALPHA-2C阻断拮抗剂
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申请号： EP14812245.0申请日： 2014-12-16
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公开(公告)号： EP3083592A2公开(公告)日： 2016-10-26
- 发明人: BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GEIß, Volker , GÖLLER, Andreas , HIMMEL, Herbert , KAST, Raimund , KNORR, Andreas , LANG, Dieter , REDLICH, Gorden , SCHMECK, Carsten , TINEL, Hanna , WUNDER, Frank
- 申请人： Bayer Pharma Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13353 Berlin DE
- 专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13353 Berlin DE
- 代理机构： BIP Patents
- 优先权： EP13198385 20131219; EP14192877 20141112
- 国际公布： WO2015091414 20150625
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D413/14 ; C07D417/14 ; C07D491/107 ; A61K31/506 ; A61K31/5377 ; A61K31/541 ; A61P7/00 ; A61P9/00 ; A61P17/02
摘要：
The invention relates to novel substituted piperidinyl-tetrahydroquinolines, methods for producing same, their use for treating and/or preventing diseases, and their use in the production of medications for treating and/or preventing diseases, particularly for treating and/or preventing diabetic microangiopathies, diabetic abscesses at extremities, particularly promoting tissue repair in diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart diseases, peripheral vascular and cardiovascular diseases, thromboembolic diseases and ischaemia, peripheral circulatory disorders, Raynaud's phenomenon, CREST syndrome, microcirculatory disorders, intermittent claudication, and peripheral and autonomic neuropathies.
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