-
1.发明公开SUBSTITUIERTE PIPERIDINYL-TETRAHYDROCHINOLINE UND IHRE VERWENDUNG ALS ALPHA-2C ADRENOREZEPTOR ANTAGONISTEN 有权被哌啶基，四氢喹啉及其作为ALPHA-2C阻断拮抗剂
公开(公告)号：EP3083592A2
公开(公告)日：2016-10-26
申请号：EP14812245.0
申请日：2014-12-16
发明人： BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GEIß, Volker , GÖLLER, Andreas , HIMMEL, Herbert , KAST, Raimund , KNORR, Andreas , LANG, Dieter , REDLICH, Gorden , SCHMECK, Carsten , TINEL, Hanna , WUNDER, Frank
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D491/107 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P7/00 , A61P9/00 , A61P17/02
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/14 , C07D417/14 , C07D491/107
摘要： The invention relates to novel substituted piperidinyl-tetrahydroquinolines, methods for producing same, their use for treating and/or preventing diseases, and their use in the production of medications for treating and/or preventing diseases, particularly for treating and/or preventing diabetic microangiopathies, diabetic abscesses at extremities, particularly promoting tissue repair in diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart diseases, peripheral vascular and cardiovascular diseases, thromboembolic diseases and ischaemia, peripheral circulatory disorders, Raynaud's phenomenon, CREST syndrome, microcirculatory disorders, intermittent claudication, and peripheral and autonomic neuropathies.
-
公开(公告)号：EP3329920A3
公开(公告)日：2019-01-09
申请号：EP17208289.3
申请日：2014-12-16
发明人： BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GEIß, Volker , GÖLLER, Andreas , HIMMEL, Herbert , KAST, Raimund , KNORR, Andreas , LANG, Dieter , REDLICH, Gorden , SCHMECK, Carsten , TINEL, Hanna , WUNDER, Frank
IPC分类号： A61K31/5377 , A61K31/506 , C07D401/14 , C07D413/14 , C07D417/14 , C07D491/107 , A61K31/541 , A61P7/00 , A61P9/00 , A61P17/02
摘要： Die Erfindung betrifft Adrenorezeptor α2C Rezeptor Antagonisten zur Verwendung in einem Verfahren zur Behandlung und/oder Prophylaxe von Begleit- und/oder Folgeerkrankungen von Diabetes mellitus, diabetischen Herzerkrankungen, diabetischen koronaren Herzerkrankungen, diabetischen koronaren mikrovaskulären Herzerkrankungen, diabetischer Herzinsuffizienz, diabetischer Kardiomyopathie und Herzinfarkt, diabetischer Mikroangiopathie, diabetischer Retinopathie, diabetischer Neuropathie, diabetischer Nephropathie, diabetischer erektiler Dysfunktion, diabetischen Geschwüren an den Extremitäten, diabetischen Fußulzera, zur Förderung der diabetischen Wundheilung und zur Förderung der Wundheilung von diabetischen Fußulzera.
-
公开(公告)号：EP3083593A1
公开(公告)日：2016-10-26
申请号：EP14812505.7
申请日：2014-12-16
发明人： BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GEIß, Volker , GÖLLER, Andreas , HIMMEL, Herbert , KAST, Raimund , KNORR, Andreas , LANG, Dieter , REDLICH, Gorden , SCHMECK, Carsten , TINEL, Hanna , WUNDER, Frank
IPC分类号： C07D401/14 , C07D413/14 , C07D491/107 , C07D495/10 , A61K31/4725
CPC分类号： C07D401/14 , A61K31/4725 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/14 , C07D491/107 , C07D495/10
摘要： The present invention relates to novel substituted piperidinyl-tetrahydroquinolines, to a method for the production thereof, to the use thereof for treating and/or preventing diseases, and to the use thereof for producing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for the promotion of wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular diseases of the heart, peripheral and cardiac vascular diseases, thromboembolic diseases and ischaemia, peripheral circulatory disorders, Raynaud's phenomenon, CREST syndrome, micro-circulation disorders, intermittent claudication, and peripheral and autonomic neuropathies.
-
公开(公告)号：EP3083592B1
公开(公告)日：2018-06-27
申请号：EP14812245.0
申请日：2014-12-16
发明人： BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GEIß, Volker , GÖLLER, Andreas , HIMMEL, Herbert , KAST, Raimund , KNORR, Andreas , LANG, Dieter , REDLICH, Gorden , SCHMECK, Carsten , TINEL, Hanna , WUNDER, Frank
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D491/107 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P7/00 , A61P9/00 , A61P17/02
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/14 , C07D417/14 , C07D491/107
-
公开(公告)号：EP3329920A2
公开(公告)日：2018-06-06
申请号：EP17208289.3
申请日：2014-12-16
发明人： BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GEIß, Volker , GÖLLER, Andreas , HIMMEL, Herbert , KAST, Raimund , KNORR, Andreas , LANG, Dieter , REDLICH, Gorden , SCHMECK, Carsten , TINEL, Hanna , WUNDER, Frank
IPC分类号： A61K31/5377 , A61K31/506 , C07D401/14 , C07D413/14 , C07D417/14 , C07D491/107 , A61K31/541 , A61P7/00 , A61P9/00 , A61P17/02
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/14 , C07D417/14 , C07D491/107
摘要： Die Erfindung betrifft Adrenorezeptor α2C Rezeptor Antagonisten zur Verwendung in einem Verfahren zur Behandlung und/oder Prophylaxe von Begleit- und/oder Folgeerkrankungen von Diabetes mellitus, diabetischen Herzerkrankungen, diabetischen koronaren Herzerkrankungen, diabetischen koronaren mikrovaskulären Herzerkrankungen, diabetischer Herzinsuffizienz, diabetischer Kardiomyopathie und Herzinfarkt, diabetischer Mikroangiopathie, diabetischer Retinopathie, diabetischer Neuropathie, diabetischer Nephropathie, diabetischer erektiler Dysfunktion, diabetischen Geschwüren an den Extremitäten, diabetischen Fußulzera, zur Förderung der diabetischen Wundheilung und zur Förderung der Wundheilung von diabetischen Fußulzera.
-
6.发明公开SUBSTITUIERTE BIPIPERIDINYL-DERIVATE ALS ADRENREZEPTOR ALPHA 2C ANTAGONISTEN 审中-公开取代的联哌啶衍生物作为ADRENREZEPTOR ALPHA 2C拮抗剂
公开(公告)号：EP3083610A1
公开(公告)日：2016-10-26
申请号：EP14815319.0
申请日：2014-12-16
发明人： BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GÖLLER, Andreas , HIMMEL, Herbert , KAST, Raimund , SCHMECK, Carsten , TINEL, Hanna , WUNDER, Frank , KELDENICH, Joerg
IPC分类号： C07D413/14 , C07D401/14 , C07D401/06 , C07D403/14 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/541 , A61P3/10
CPC分类号： C07D401/14 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/06 , C07D403/14 , C07D413/14 , C07D491/107
摘要： The invention relates to novel substituted bipiperidinyl derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, especially for promotion of wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulation disorders, Raynaud phenomena, CREST syndrome, microcirculation disorders, intermittent claudication, and peripheral and autonomous neuropathies.
-
7.发明公开SUBSTITUIERTE BIPIPERIDINYL-DERIVATE ALS ADRENOREZEPTOR ALPHA 2C ANTAGONISTEN 审中-公开取代联哌啶衍生物作为支撑ALPHA 2C受体拮抗剂
公开(公告)号：EP3083594A1
公开(公告)日：2016-10-26
申请号：EP14815662.3
申请日：2014-12-16
发明人： BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GNOTH, Mark Jean , HIMMEL, Herbert , KAST, Raimund , KLAR, Jürgen , KNORR, Andreas , LANG, Dieter , LINDNER, Niels , SCHMECK, Carsten , SCHOHE-LOOP, Rudolf , TINEL, Hanna , TRÜBEL, Hubert , WUNDER, Frank
IPC分类号： C07D401/14 , C07D211/16 , C07D211/22 , C07D211/42 , C07D401/12 , C07D403/04 , C07D413/04 , C07D413/10 , C07D413/12 , A61K31/4468 , A61K31/4523 , A61P3/10 , A61P9/00
CPC分类号： C07D211/10 , A61K31/4545 , A61K45/06 , C07D211/16 , C07D211/22 , C07D211/42 , C07D211/60 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The invention relates to novel substituted bipiperidinyl derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, especially for promotion of wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulation disorders, Raynaud phenomena, CREST syndrome, microcirculation disorders, intermittent claudication, and peripheral and autonomous neuropathies.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.03 秒)
