发明公开
- 专利标题： HIV PROTEASE INHIBITORS
- 专利标题（中）： HIV-PROTEASEHEMMER
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申请号： EP14872077申请日： 2014-12-17
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公开(公告)号： EP3083609A4公开(公告)日： 2017-05-31
- 发明人: MCCAULEY JOHN A , BEAULIEU CHRISTIAN , BENNETT DAVID JONATHAN , BUNGARD CHRISTOPHER J , CRANE SHELDON , GRESHOCK THOMAS J , HOLLOWAY M KATHARINE , JUTEAU HELEN , MCKAY DANIEL , MOLINARO CARMELA , MORADEI OSCAR MIGUEL , NADEAU CHRISTIAN , SIMARD DANIEL , TUMMANAPALLI SATYANARAYANA , TRUONG VOUY LINH , VILLENEUVE KARINE M , WILLIAMS PETER D
- 申请人： MERCK SHARP & DOHME , MERCK CANADA INC
- 专利权人： MERCK SHARP & DOHME,MERCK CANADA INC
- 当前专利权人： MERCK SHARP & DOHME,MERCK CANADA INC
- 优先权： US201361918013 2013-12-19
- 主分类号： C07D413/04
- IPC分类号： C07D413/04 ; A61K31/5377 ; A61P31/18 ; C07D265/32 ; C07D413/12 ; C07D413/14 ; C07D417/04 ; C07D471/04 ; C07D487/04
摘要：
The present invention is directed to 5-heteroarylmorpholine derivatives and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
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