发明公开
- 专利标题： INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
- 专利标题（中）： 肾上腺延髓钾通道抑制剂
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申请号： EP14875049.0申请日： 2014-12-19
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公开(公告)号： EP3087077A1公开(公告)日： 2016-11-02
- 发明人: DONG, Shuzhi , PASTERNAK, Alexander , GU, Xin , FU, Qinghong , JIANG, Jinlong , DING, Fa-Xiang , TANG, Haifeng , DEJESUS, Reynalda, K. , SUZUKI, Takao
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Jaap, David Robert
- 优先权： PCT/CN2013/090335 20131224
- 国际公布： WO2015100147 20150702
- 主分类号： C07D487/10
- IPC分类号： C07D487/10 ; C07D471/10
摘要：
Novel spirocyclic compounds of formula I: and pharmaceutically acceptable salts thereof are disclosed as inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention. Pharmaceutical compositions and methods of treatment are also included.
公开/授权文献
- EP3087077B1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL 公开/授权日：2018-10-31
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