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公开(公告)号：EP3063142A1
公开(公告)日：2016-09-07
申请号：EP14856853.8
申请日：2014-10-27
发明人： PASTERNAK, Alexander , TANG, Haifeng , FRIE, Jessica , FERGUSON, Ronald Dale , GUO, Zhiqiang , SHI, Zhi-Cai , CATO, Brian , FU, Qinghong
IPC分类号： C07D405/06
CPC分类号： C07D405/06 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K45/06 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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公开(公告)号：EP3212618A1
公开(公告)日：2017-09-06
申请号：EP15854736.4
申请日：2015-10-26
发明人： PASTERNAK, Alexander , DING, Fa-Xiang , DONG, Shuzhi , JIANG, Jinlong , TANG, Haifeng , GU, Xin , DEJESUS, Reynalda K. , FRIE, Jessica , FU, Qinghong , SUZUKI, Takao , PU, Zhifa
IPC分类号： C07D211/28 , C07D211/62
CPC分类号： C07D471/10 , A61K31/401 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/435 , A61K31/4422 , A61K31/499 , A61K31/537 , A61K31/5386 , A61K31/55 , A61K31/553 , A61K45/06 , C07D487/10 , C07D498/10 , C07D498/20 , A61K2300/00
摘要： The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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公开(公告)号：EP3063142B1
公开(公告)日：2019-01-30
申请号：EP14856853.8
申请日：2014-10-27
发明人： PASTERNAK, Alexander , TANG, Haifeng , FRIE, Jessica , FERGUSON, Ronald Dale , GUO, Zhiqiang , SHI, Zhi-Cai , CATO, Brian , FU, Qinghong
IPC分类号： C07D405/06
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公开(公告)号：EP3087077B1
公开(公告)日：2018-10-31
申请号：EP14875049.0
申请日：2014-12-19
发明人： DONG, Shuzhi , PASTERNAK, Alexander , GU, Xin , FU, Qinghong , JIANG, Jinlong , DING, Fa-Xiang , TANG, Haifeng , DEJESUS, Reynalda, K. , SUZUKI, Takao
IPC分类号： C07D471/10 , C07D498/10 , A61K31/435 , A61K31/537 , A61P9/00
CPC分类号： A61K31/435 , A61K31/437 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/537 , A61K45/06 , C07D471/10 , C07D498/10 , C07D519/00 , A61K2300/00
摘要： Novel spirocyclic compounds of formula I: and pharmaceutically acceptable salts thereof are disclosed as inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention. Pharmaceutical compositions and methods of treatment are also included.
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公开(公告)号：EP3087077A1
公开(公告)日：2016-11-02
申请号：EP14875049.0
申请日：2014-12-19
发明人： DONG, Shuzhi , PASTERNAK, Alexander , GU, Xin , FU, Qinghong , JIANG, Jinlong , DING, Fa-Xiang , TANG, Haifeng , DEJESUS, Reynalda, K. , SUZUKI, Takao
IPC分类号： C07D487/10 , C07D471/10
CPC分类号： A61K31/435 , A61K31/437 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/537 , A61K45/06 , C07D471/10 , C07D498/10 , C07D519/00 , A61K2300/00
摘要： Novel spirocyclic compounds of formula I: and pharmaceutically acceptable salts thereof are disclosed as inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 式I的新型螺环化合物及其药学上可接受的盐被公开为ROMK（Kir1.1）通道的抑制剂。 这些化合物可以用作利尿剂和/或利尿钠剂，并用于治疗和预防医学病症，包括心血管疾病如高血压，心力衰竭和慢性肾病以及与过量的盐和水潴留有关的病症。 药物组合物和治疗方法也包括在内。
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公开(公告)号：EP3250204B1
公开(公告)日：2019-10-30
申请号：EP16743895.1
申请日：2016-01-25
IPC分类号： A61K31/438 , A61P9/12 , C07D471/10
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公开(公告)号：EP3212618B1
公开(公告)日：2019-07-10
申请号：EP15854736.4
申请日：2015-10-26
发明人： PASTERNAK, Alexander , DING, Fa-Xiang , DONG, Shuzhi , JIANG, Jinlong , TANG, Haifeng , GU, Xin , DEJESUS, Reynalda K. , FRIE, Jessica , FU, Qinghong , SUZUKI, Takao , PU, Zhifa
IPC分类号： C07D471/10 , C07D487/10 , C07D498/10 , C07D498/20 , A61K31/401 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/435 , A61K31/4422 , A61P3/10 , A61P9/00 , A61P13/02 , A61P13/12
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公开(公告)号：EP3250204A1
公开(公告)日：2017-12-06
申请号：EP16743895.1
申请日：2016-01-25
IPC分类号： A61K31/438 , A61P9/12 , C07D471/10
摘要： The present invention provides compounds of Formula I (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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公开(公告)号：EP3212616A1
公开(公告)日：2017-09-06
申请号：EP15854604.4
申请日：2015-10-26
发明人： PASTERNAK, Alexander , DONG, Shuzhi , GU, Xin , JIANG, Jinlong , SHI, Zhi-Cai , WALSH, Shawn P. , WU, Zhicai , YU, Yang , FERGUSON, Ronald II , GUO, Zhiqiang , FRIE, Jessica , SUZUKI, Takao , BLIZZARD, Timothy A. , FU, Qinghong , VANGELDER, Kelsey F.
IPC分类号： C07D211/28 , C07D211/62
CPC分类号： C07D498/10 , A61K31/401 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/435 , A61K31/4422 , A61K31/444 , A61K31/4965 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/519 , A61K31/5386 , A61K31/55 , A61K31/551 , A61K31/585 , A61K31/675 , A61P3/14 , A61P7/10 , A61P9/12 , C07D471/10 , C07D497/10 , A61K2300/00
摘要： The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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公开(公告)号：EP2755656B1
公开(公告)日：2016-09-07
申请号：EP12832050.4
申请日：2012-09-10
发明人： WALSH, Shawn , PASTERNAK, Alexander , CATO, Brian , FINKE, Paul, E. , FRIE, Jessica , FU, Qinghong , KIM, Dooseop , PIO, Barbara , SHAHRIPOUR, Aurash , SHI, Zhi-Cai , TANG, Haifeng
IPC分类号： C07D211/28 , C07D211/48 , C07D211/62 , C07D401/10 , C07D403/10 , C07D405/06 , C07D405/12 , C07D405/14 , C07D471/08 , C07D487/04 , A61K31/445 , A61P9/00 , A61P9/12 , A61P13/12
CPC分类号： C07D401/10 , C07D211/28 , C07D211/48 , C07D211/62 , C07D403/10 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/14 , C07D471/08 , C07D487/04
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