发明公开
EP3099325A4 METHODS OF TREATING AND IMAGING TUMOR MICROMETASTASES USING PHOTOACTIVATABLE IMMUNOCONJUGATES
审中-公开
VERFAHREN ZUR BEHANDLUNG ANDD BILDGEBUNG VON TUMORMIKROMETASTASEN MITTELS LICHTAKTIVIERBARER IMMUNKONJUGATE
- 专利标题： METHODS OF TREATING AND IMAGING TUMOR MICROMETASTASES USING PHOTOACTIVATABLE IMMUNOCONJUGATES
- 专利标题（中）： VERFAHREN ZUR BEHANDLUNG ANDD BILDGEBUNG VON TUMORMIKROMETASTASEN MITTELS LICHTAKTIVIERBARER IMMUNKONJUGATE
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申请号： EP15743124申请日： 2015-02-02
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公开(公告)号： EP3099325A4公开(公告)日： 2017-10-04
- 发明人: HASAN TAYYABA , SPRING BRYAN Q , PALANASAMI AKILAN
- 申请人： THE GENERAL HOSPITAL CORP DBA MASSACHUSETTS GENERAL HOSPITAL
- 专利权人： THE GENERAL HOSPITAL CORP DBA MASSACHUSETTS GENERAL HOSPITAL
- 当前专利权人： THE GENERAL HOSPITAL CORP DBA MASSACHUSETTS GENERAL HOSPITAL
- 优先权： US201461934210 2014-01-31
- 主分类号： A61K41/00
- IPC分类号： A61K41/00 ; A61K49/00 ; A61P35/04 ; G01J1/48
摘要：
Methods for evaluating micrometastases in a tissue region of a subject are described. The methods include administering to the subject a detectably effective amount of a tumor-targeted photoactivatable immunoconjugate; allowing a sufficient amount of time for the tumor-targeted photoactivatable immunoconjugate to enter micrometastases in the tissue region; illuminating the tumor-targeted photoactivatable immunoconjugate; obtaining an image of the tissue region of the subject using a fluorescent imaging device, and evaluating the micrometastases in the tissue region by conducting algorithmic analysis of the image. Methods of treating micrometastases in a tissue region of a subject are also described.
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