利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

1 条记录 (耗时 0.009 秒)

    METHODS OF TREATING AND IMAGING TUMOR MICROMETASTASES USING PHOTOACTIVATABLE IMMUNOCONJUGATES
    1.
    发明公开
    METHODS OF TREATING AND IMAGING TUMOR MICROMETASTASES USING PHOTOACTIVATABLE IMMUNOCONJUGATES 审中-公开
    VERFAHREN ZUR BEHANDLUNG ANDD BILDGEBUNG VON TUMORMIKROMETASTASEN MITTELS LICHTAKTIVIERBARER IMMUNKONJUGATE

    公开(公告)号：EP3099325A4

    公开(公告)日：2017-10-04

    申请号：EP15743124

    申请日：2015-02-02

    申请人： THE GENERAL HOSPITAL CORP DBA MASSACHUSETTS GENERAL HOSPITAL

    发明人： HASAN TAYYABA ,  SPRING BRYAN Q ,  PALANASAMI AKILAN

    IPC分类号： A61K41/00 ,  A61K49/00 ,  A61P35/04 ,  G01J1/48

    CPC分类号： A61B5/0071 ,  A61B1/00009 ,  A61B1/00057 ,  A61B1/043 ,  A61B5/4325 ,  A61B5/7203 ,  A61B5/725 ,  A61K41/0057 ,  A61K49/0036 ,  A61K49/0058 ,  G01J1/48

    摘要： Methods for evaluating micrometastases in a tissue region of a subject are described. The methods include administering to the subject a detectably effective amount of a tumor-targeted photoactivatable immunoconjugate; allowing a sufficient amount of time for the tumor-targeted photoactivatable immunoconjugate to enter micrometastases in the tissue region; illuminating the tumor-targeted photoactivatable immunoconjugate; obtaining an image of the tissue region of the subject using a fluorescent imaging device, and evaluating the micrometastases in the tissue region by conducting algorithmic analysis of the image. Methods of treating micrometastases in a tissue region of a subject are also described.

    摘要翻译： 描述了用于评估受试者的组织区域中的微转移的方法。 所述方法包括向受试者施用可检测有效量的肿瘤靶向光可激活免疫缀合物; 允许足够的时间用于肿瘤靶向的可光活化的免疫缀合物进入组织区域中的微转移; 照亮肿瘤靶向的可光活化的免疫缀合物; 使用荧光成像装置获得对象的组织区域的图像，并通过对图像进行算法分析来评估组织区域中的微转移。 还描述了在受试者的组织区域中治疗微转移的方法。