发明公开
- 专利标题： TABLET FORMULATION FOR CGRP-ACTIVE COMPOUNDS
- 专利标题（中）： 片剂制剂CGRP活性化合物
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申请号： EP15746768.9申请日： 2015-01-30
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公开(公告)号： EP3102564A1公开(公告)日： 2016-12-14
- 发明人: JOHNSON, Mary Ann , ALLAIN, Leonardo Resende , EICKHOFF, W. Mark , IKEDA, Craig, B. , BROWN, Chad, D. , FLANAGAN, Francis, J., Jr. , NOFSINGER, Rebecca , MAROTA, Melanie , LUPTON, Lisa , PATEL, Paresh, B. , XI, Hanmi , XU, Wei
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US201461936019P 20140205; US201462087366P 20141204
- 国际公布： WO2015119848 20150813
- 主分类号： C07D221/02
- IPC分类号： C07D221/02 ; A61K31/437 ; A61K9/26
摘要：
The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API): Formula I, wherein "R
a " is independently H or -F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.
a " is independently H or -F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.
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