公开(公告)号：EP3102564A1

公开(公告)日：2016-12-14

申请号：EP15746768.9

申请日：2015-01-30

申请人： Merck Sharp & Dohme Corp.

发明人： JOHNSON, Mary Ann ,  ALLAIN, Leonardo Resende ,  EICKHOFF, W. Mark ,  IKEDA, Craig, B. ,  BROWN, Chad, D. ,  FLANAGAN, Francis, J., Jr. ,  NOFSINGER, Rebecca ,  MAROTA, Melanie ,  LUPTON, Lisa ,  PATEL, Paresh, B. ,  XI, Hanmi ,  XU, Wei

IPC分类号： C07D221/02 ,  A61K31/437 ,  A61K9/26

CPC分类号： A61K9/2077 ,  A61K9/146 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K31/437 ,  A61K31/4545

摘要： The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API): Formula I, wherein "R
a " is independently H or -F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.