发明公开
EP3102569A1 6-HETEROARYLOXY- AND 6-ARYLOXY-QUINOLINE-2-CARBOXAMIDES AND USES THEREOF
审中-公开
6-杂芳氧基和6-芳氧基喹啉-2-羧酰胺和其用途
- 专利标题： 6-HETEROARYLOXY- AND 6-ARYLOXY-QUINOLINE-2-CARBOXAMIDES AND USES THEREOF
- 专利标题（中）： 6-杂芳氧基和6-芳氧基喹啉-2-羧酰胺和其用途
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申请号： EP15705447.9申请日： 2015-02-04
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公开(公告)号： EP3102569A1公开(公告)日： 2016-12-14
- 发明人: BOGDAN, Andrew , COWART, Marlon D. , DEGOEY, DavidA. , JINKERSON, Tammie, K. , KOENIG, John R. , KORT, Michael E. , LIU, Bo , MATULENKO, Mark A. , NELSON, Derek W. , PATEL, Meena V. , PELTIER, Hillary , SCANIO, Marc J. , WAKEFIELD, Brian D.
- 申请人： AbbVie Inc.
- 申请人地址： 1 North Waukegan Road AP06A - V0377 Chicago, IL 60064 US
- 专利权人： AbbVie Inc.
- 当前专利权人： AbbVie Inc.
- 当前专利权人地址： 1 North Waukegan Road AP06A - V0377 Chicago, IL 60064 US
- 代理机构： Modiano, Micaela Nadia
- 优先权： US201461936397P 20140206
- 国际公布： WO2015119998 20150813
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D215/48 ; C07D401/12 ; C07D405/12 ; C07D409/12 ; C07D417/12 ; C07D487/04 ; C07D487/08 ; A61K31/498 ; A61K31/4709 ; A61K31/5377 ; A61P25/00 ; A61P29/00
摘要：
Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
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