发明公开
EP3107541A1 COMPOUNDS FOR TREATING PATIENTS WITH ROS1 MUTANT CANCER CELLS
审中-公开
VERBINDUNGEN ZUR BEHANDLUNG VON PATIENTEN MIT MUTANTEN ROS1-KREBSZELLEN
- 专利标题： COMPOUNDS FOR TREATING PATIENTS WITH ROS1 MUTANT CANCER CELLS
- 专利标题（中）： VERBINDUNGEN ZUR BEHANDLUNG VON PATIENTEN MIT MUTANTEN ROS1-KREBSZELLEN
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申请号： EP15705613.6申请日： 2015-02-19
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公开(公告)号： EP3107541A1公开(公告)日： 2016-12-28
- 发明人: LIM, Jonathan , ARDINI, Elena , MENICHINCHERI, Maria
- 申请人： Ignyta, Inc. , Nerviano Medical Sciences S.r.l.
- 申请人地址： 11111 Flintkote Avenue San Diego, CA 92121 US
- 专利权人： Ignyta, Inc.,Nerviano Medical Sciences S.r.l.
- 当前专利权人： Ignyta, Inc.,Nerviano Medical Sciences S.r.l.
- 当前专利权人地址： 11111 Flintkote Avenue San Diego, CA 92121 US
- 代理机构： Carpmaels & Ransford LLP
- 优先权： US201461942287P 20140220; US201462052994P 20140919; US201462055450P 20140925; US201462069999P 20141029
- 国际公布： WO2015124697 20150827
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; A61P35/04 ; A61P35/00
摘要：
Substituted indazole derivatives of formula (I) or formula 2.(I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
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