公开(公告)号：EP3834827A1

公开(公告)日：2021-06-16

申请号：EP20207234.4

申请日：2015-02-19

申请人： Ignyta, Inc. ,  Nerviano Medical Sciences S.r.l.

发明人： LIM, Jonathan ,  ARDINI, Elena ,  MENICHINCHERI, Maria

IPC分类号： A61K31/496 ,  A61P35/04 ,  A61P35/00

摘要： Substituted indazole derivatives of formula (I) or formula 2.(I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.

公开(公告)号：EP3107541A1

公开(公告)日：2016-12-28

申请号：EP15705613.6

申请日：2015-02-19

申请人： Ignyta, Inc. ,  Nerviano Medical Sciences S.r.l.

发明人： LIM, Jonathan ,  ARDINI, Elena ,  MENICHINCHERI, Maria

IPC分类号： A61K31/496 ,  A61P35/04 ,  A61P35/00

CPC分类号： A61K31/496

摘要： Substituted indazole derivatives of formula (I) or formula 2.(I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.

摘要翻译： 公开了本说明书中定义的式（I）或式（I）的取代的吲唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。