发明公开
EP3113796A1 METHOD OF USING ANTIBODY POLYPEPTIDES THAT ANTAGONIZE CD40 TO TREAT IBD
审中-公开
使用方法抗体多肽与CD40拮抗炎性肠道疾病的治疗
- 专利标题： METHOD OF USING ANTIBODY POLYPEPTIDES THAT ANTAGONIZE CD40 TO TREAT IBD
- 专利标题（中）： 使用方法抗体多肽与CD40拮抗炎性肠道疾病的治疗
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申请号： EP15710401.9申请日： 2015-03-09
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公开(公告)号： EP3113796A1公开(公告)日： 2017-01-11
- 发明人: HONCZARENKO, Marek , SHAH, Vaishali , LIU, Xiaoni , TRIGONA, Wendy L. , SHI, Rong , SUCHARD, Suzanne J. , PRICE, Karen D. , GUSTAVSON, Linda M.
- 申请人： Bristol-Myers Squibb Company
- 申请人地址： Route 206 and Province Line Road Princeton, NJ 08543 US
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： Route 206 and Province Line Road Princeton, NJ 08543 US
- 代理机构： Reitstötter Kinzebach
- 优先权： US201461949876P 20140307
- 国际公布： WO2015134988 20150911
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P1/00 ; A61P29/02
摘要：
A method of treating an inflammatory bowel disease is provided. The method comprises administration of an antibody polypeptide that specifically binds a novel epitope of human CD40. The antibody polypeptides do not exhibit CD40 agonist activity. The antibody polypeptides may be fusions of a domain antibody (dAb) comprising a single V
L or V
H domain and an Fc domain.
L or V
H domain and an Fc domain.
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