发明公开
EP3116859A1 NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
审中-公开
作为组合物的新化合物DEACETYLASE 6抑制剂和包含该化合物的药物组合物
- 专利标题： NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
- 专利标题（中）： 作为组合物的新化合物DEACETYLASE 6抑制剂和包含该化合物的药物组合物
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申请号： EP15762410.7申请日： 2015-03-12
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公开(公告)号： EP3116859A1公开(公告)日： 2017-01-18
- 发明人: SONG, Hyeseung , LEE, Changgon , KWAK, Dalyong , LEE, Jaeyoung , BAE, Suyeal , KIM, Yuntae , BAE, Daekwon , HA, Nina , BAE, Miseon , KIM, Jihyun
- 申请人： Chong Kun Dang Pharmaceutical Corp.
- 申请人地址： 8 Chungjeong-ro Seodaemun-gu Seoul 03742 KR
- 专利权人： Chong Kun Dang Pharmaceutical Corp.
- 当前专利权人： Chong Kun Dang Pharmaceutical Corp.
- 当前专利权人地址： 8 Chungjeong-ro Seodaemun-gu Seoul 03742 KR
- 代理机构： D Young & Co LLP
- 优先权： KR20140028920 20140312
- 国际公布： WO2015137750 20150917
- 主分类号： C07D241/12
- IPC分类号： C07D241/12 ; A61K31/496 ; A61P29/00 ; C07D241/04
摘要：
The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) inhibitory activity, isomers thereof, or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions comprising the same, a method of treating disease using the composition, and methods for preparing the novel compounds. The novel compounds according to the present invention have histone deacetylase 6 (HDAC6) inhibitory activity, and are effective for the prevention or treatment of HDAC6-associated diseases, including cancer, inflammatory diseases, autoimmune diseases, neurological diseases and neurodegenerative disorders.
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