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    NOVEL AZAINDOLE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE (HDAC) INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
    2.
    发明公开
    NOVEL AZAINDOLE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE (HDAC) INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 审中-公开
    中性粒细胞坏死因子乙酰胆碱酯酶（HDAC） - 抗生素在药物化合物ZUSAMMENSETZUNGEN DAMIT

    公开(公告)号：EP3080125A1

    公开(公告)日：2016-10-19

    申请号：EP14869323.7

    申请日：2014-12-12

    申请人： Chong Kun Dang Pharmaceutical Corp.

    发明人： LEE, Changsik ,  YANG, Hyun-mo ,  LEE, Changkon ,  BAE, Miseon ,  KIM, Soyoung ,  CHOI, Youngil ,  HA, Nina ,  LEE, Jaekwang ,  OH, Jungtaek ,  SONG, Hyeseung ,  KIM, Ilhyang ,  CHOI, Daekyu ,  MIN, Jaeki ,  LIM, Hyojin ,  BAE, Daekwon

    IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D401/04 ,  A61K31/437

    CPC分类号： C07D471/04 ,  C07D519/00

    摘要： The present invention relates to novel azaindole derivatives, and more particularly, to novel azaindole derivatives having histone deacetylase (HDAC) inhibitory activity, isomers thereof, pharmaceutically acceptable salts thereof, hydrates thereof or solvates thereof, the use thereof for the preparation of pharmaceutical compositions, pharmaceutical compositions containing the same, a method of treating disease using the pharmaceutical compositions, and methods for preparing the novel azaindole derivatives. The novel azaindole derivatives according to the present invention are selective histone deacetylase (HDAC) inhibitors, and may be used as agents for treating malignant tumor diseases, inflammatory diseases, rheumatoid arthritis, and neurodegenerative diseases.

    摘要翻译： 本发明涉及新颖的氮杂吲哚衍生物，更具体地说，涉及具有组蛋白脱乙酰酶（HDAC）抑制活性的新型氮杂吲哚衍生物，其异构体，药学上可接受的盐，其水合物或溶剂合物，其用于制备药物组合物的用途， 含有该组合物的药物组合物，使用该药物组合物治疗疾病的方法，以及制备该新颖的氮杂吲哚衍生物的方法。 根据本发明的新颖的氮杂吲哚衍生物是选择性组蛋白脱乙酰酶（HDAC）抑制剂，可用作治疗恶性肿瘤疾病，炎症性疾病，类风湿性关节炎和神经变性疾病的药剂。