A communication control method and a related apparatus are disclosed. A communication control method includes: transmitting, by a base station, a configuration message to N user terminals in a cell, where the configuration message carries a secondary configuration indication, and the secondary configuration indication is used to indicate a secondary transmission configuration configured by the base station for the N user terminals, where the secondary transmission configuration of the N user terminals is different from a primary transmission configuration of M user terminals in the cell; obtaining, by the base station, interference parameters about interference that the N user terminals receive from neighboring user terminals in a full-duplex subframe; and activating, by the base station, the secondary transmission configuration for K user terminals in the N user terminals by using an activation message. Solutions of embodiments of the present invention help to apply a full-duplex technology while minimizing changes to a user terminal.