In the context of a method for the analysis of image data representing a three-dimensional volume of biological tissue, the image data comprises a first image representing the volume at a first point in time and a second image representing the volume at a second point in time being different from the first point in time. The method comprises the steps of: a) identifying a first subvolume of the volume represented by the first image having a major extension in a predefined direction and a second subvolume of the volume represented by the second image having a major extension in the predefined direction, whereas the first subvolume and the second subvolume represent a same region of the three-dimensional volume; b) creating a distance matrix from image data of a succession of voxels of the first subvolume in the predefined direction and image data of a succession of voxels of the second subvolume in the predefined direction; and c) analyzing the distance matrix to obtain at least one local measure for a probability of growth of a layer of the biological tissue represented by the first and the second subvolume, along the predefined direction.