- 专利标题: METHOD FOR PRODUCING HETEROCYCLIC COMPOUND
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申请号: EP15777381申请日: 2015-04-09
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公开(公告)号: EP3130581A4公开(公告)日: 2017-11-22
- 发明人: YAMASHITA HIRONORI , MIWA KAZUHIRO
- 申请人: TAKEDA PHARMACEUTICALS CO
- 专利权人: TAKEDA PHARMACEUTICALS CO
- 当前专利权人: TAKEDA PHARMACEUTICALS CO
- 优先权: JP2014080984 2014-04-10
- 主分类号: C07C231/02
- IPC分类号: C07C231/02 ; C07B61/00 ; C07C231/18 ; C07C233/58 ; C07D211/60
摘要:
Provided is a production method of a synthetic intermediate for a heterocyclic compound having a renin inhibitory activity and useful as a prophylactic or therapeutic drug for diabetic nephropathy, hypertension and the like. A production method of a compound represented by the formula (III-1a), the formula (III-1b), the formula (III-1c) and/or the formula (III-1d); wherein each symbol is as described in DESCRIPTION, or a salt thereof, including reacting a compound represented by the formula (Ia) or (Ib): wherein each symbol is as described in DESCRIPTION, or a salt thereof with a compound represented by the formula (II): wherein each symbol is as described in DESCRIPTION, or a salt thereof, in the presence of an aluminum compound and a chiral amine compound.
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