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公开(公告)号：EP3210971A4
公开(公告)日：2018-06-06
申请号：EP15853036
申请日：2015-10-22
发明人： BANNO YOSHIHIRO , KAMAURA MASAHIRO , TANIGUCHI TAKAHIKO , TAKAMI KAZUAKI , FUKUDA KOICHIRO , SASAKI SHIGEKAZU
IPC分类号： C07D207/08 , A61K31/40 , A61K31/401 , A61P27/02 , A61P43/00 , C12N15/09
CPC分类号： C07D207/08 , A61K31/40 , A61K31/401 , C12N15/09
摘要： Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4. A compound represented by the formula (I): wherein each symbol is as defined in the Description, or a salt thereof has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.
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公开(公告)号：EP3130581A4
公开(公告)日：2017-11-22
申请号：EP15777381
申请日：2015-04-09
发明人： YAMASHITA HIRONORI , MIWA KAZUHIRO
IPC分类号： C07C231/02 , C07B61/00 , C07C231/18 , C07C233/58 , C07D211/60
CPC分类号： C07D211/60 , C07C231/02 , C07C231/08 , C07C2101/02 , C07C2101/08 , C07C2101/16 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D401/06 , C07C233/58
摘要： Provided is a production method of a synthetic intermediate for a heterocyclic compound having a renin inhibitory activity and useful as a prophylactic or therapeutic drug for diabetic nephropathy, hypertension and the like. A production method of a compound represented by the formula (III-1a), the formula (III-1b), the formula (III-1c) and/or the formula (III-1d); wherein each symbol is as described in DESCRIPTION, or a salt thereof, including reacting a compound represented by the formula (Ia) or (Ib): wherein each symbol is as described in DESCRIPTION, or a salt thereof with a compound represented by the formula (II): wherein each symbol is as described in DESCRIPTION, or a salt thereof, in the presence of an aluminum compound and a chiral amine compound.
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公开(公告)号：EP3133075A4
公开(公告)日：2017-09-20
申请号：EP15779993
申请日：2015-04-16
发明人： OKANIWA MASANORI , BANNO HIROSHI , HIRAYAMA TAKAHARU , CARY DOUGLAS ROBERT , ONO KOJI , IWAMURA NAOKI
IPC分类号： C07D513/04 , A61K31/429 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/5377 , A61P35/00 , A61P35/02 , A61P43/00
CPC分类号： C07D513/04 , A61K31/429 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/5377
摘要： The present invention provides a fused heterocyclic compound that has CDK 8 and/or CDK 19 inhibitory activity. The present invention provides a compound represented by formula (I) (wherein the symbols are as defined in the description) or a salt thereof.
摘要翻译： 本发明提供具有CDK8和/或CDK19抑制活性的稠合杂环化合物。 本发明提供由式（I）表示的化合物或其盐，其中符号如说明书中所定义。
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公开(公告)号：EP2974768A4
公开(公告)日：2017-05-17
申请号：EP14763171
申请日：2014-03-11
CPC分类号： A61M37/0015 , A61K9/0021 , A61K9/7092 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , B29C45/0053 , B29C45/1615 , B29K2101/12 , B29K2995/0056 , B29L2009/00 , B29L2031/753
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公开(公告)号：EP3210973A4
公开(公告)日：2018-04-25
申请号：EP15853151
申请日：2015-10-22
IPC分类号： C07D213/65 , A61K31/415 , A61K31/421 , A61K31/4418 , A61K31/505 , A61P27/02
CPC分类号： A61K31/415 , A61K31/421 , A61K31/4418 , A61K31/505 , C07D213/65 , C07D231/12 , C07D231/22 , C07D239/34 , C07D263/38 , C07K14/47 , C12N15/09
摘要： Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4. A compound represented by the formula (I): wherein each symbol is as defined in the Description, or a salt thereof has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.
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公开(公告)号：EP3192791A4
公开(公告)日：2018-03-28
申请号：EP15840620
申请日：2015-09-10
发明人： YAMAMOTO SATOSHI , SHIRAI JUNYA , ODA TSUNEO , IMADA TAKASHI , KONO MITSUNORI , SATO AYUMU , TOMATA YOSHIHIDE , OCHIDA ATSUKO , ISHII NAOKI , SASAKI YUSUKE , FUKASE YOSHIYUKI , YUKAWA TOMOYA , FUKUMOTO SHOJI
IPC分类号： C07D239/96 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P1/00 , A61P11/00
CPC分类号： C07D471/04 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P1/00 , A61P11/00 , C07D239/96 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The problem of the present invention is to provide a compound having a superior ROR³t inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like. The present invention relates to a compound represented by the formula (I): [wherein each symbol is as described in the DESCRIPTION] or a salt thereof, which has an ROR³t inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like.
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公开(公告)号：EP3178807A4
公开(公告)日：2018-03-28
申请号：EP15829025
申请日：2015-08-06
发明人： HOASHI YASUTAKA
IPC分类号： C07C229/12 , A61K9/127 , A61K9/51 , A61K31/7105 , A61K31/713 , A61K47/18 , A61K48/00 , A61P43/00 , C12N15/113
CPC分类号： C07C69/34 , A61K9/08 , A61K9/107 , A61K9/127 , A61K31/7105 , A61K31/713 , A61K47/18 , A61K48/00 , C07C229/12 , C11C3/003 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要： The present invention provides a technology which enables introduction of an active ingredient (e.g. nucleic acids) into various cells with a high efficiency, and compounds used therefor. The present invention provides a compound represented by the formula: [wherein, each symbol is as defined in the present description] or a salt thereof.
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公开(公告)号：EP3120871A4
公开(公告)日：2017-10-18
申请号：EP15764152
申请日：2015-03-17
发明人： NOMURA YUKIHIRO , TSUSHIMA YUKI , EBISAWA YUTAKA
IPC分类号： A61K47/38 , A61K9/14 , A61K31/4422 , A61K47/32
CPC分类号： A61K9/146 , A61K9/145 , A61K31/4422 , A61K31/501 , B01J2/22 , B29B9/10 , B29K2001/08 , B29K2105/0035
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公开(公告)号：EP3205645A4
公开(公告)日：2017-08-30
申请号：EP15780012
申请日：2015-04-16
IPC分类号： C07D213/64 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4704 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/499 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/553 , A61P35/00 , A61P43/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4704 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/499 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/553 , C07D213/64 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/107 , C07D498/08
摘要： The present invention provides a heterocyclic compound having a CDK8 and/or CDK19 inhibitory effect. The present invention provides a compound represented by formula (I) (in the formula, the symbols are as defined in the description) or a salt thereof.
摘要翻译： 本发明提供具有CDK8和/或CDK19抑制作用的杂环化合物。 本发明提供由式（I）表示的化合物或其盐，其中，符号如说明书中所定义。
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公开(公告)号：EP3085357A4
公开(公告)日：2017-05-24
申请号：EP14870738
申请日：2014-12-15
IPC分类号： A61K9/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K47/10 , A61K47/24 , A61K47/26 , A61K47/36
CPC分类号： A61K9/0021 , A61K39/08 , A61K39/12 , A61K47/26 , A61K47/36 , A61K47/40 , A61K2039/5258 , A61K2039/54 , C12N7/00 , C12N2770/16023 , C12N2770/16034
摘要： In order to configure a microneedle to be more suitable for administering a vaccine antigen, the present invention is a formulation having a dissolving-type microspike which is used as a microneedle in which a vaccine antigen is stabilized, and which includes a vaccine antigen, an ionic polymer base material, and at least one species selected from the group consisting of a non-reducing sugar, a sugar alcohol, cyclodextrin, and a surfactant.
摘要翻译： 为了使微针更适于给予疫苗抗原，本发明是一种制剂，其具有作为疫苗抗原稳定的微针使用的溶解型微型抽吸针，其包含疫苗抗原， 离子性聚合物基础材料，以及选自非还原糖，糖醇，环糊精和表面活性剂中的至少一种。
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