发明公开
- 专利标题： TCR(ALPHA)-LCR-DERIVED GENE REGULATORY CASSETTES
- 专利标题（中）： TCR（ALPHA）-LCR衍生的基因调控载体
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申请号： EP15789568.1申请日： 2015-05-11
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公开(公告)号： EP3140407A1公开(公告)日： 2017-03-15
- 发明人: ORTIZ, Benjamin, D. , LAHIJI, Armin
- 申请人： Research Foundation Of The City University Of New York
- 申请人地址： 555 West 57th Street Suite 1407 New York, NY 10019 US
- 专利权人： Research Foundation Of The City University Of New York
- 当前专利权人： Research Foundation Of The City University Of New York
- 当前专利权人地址： 555 West 57th Street Suite 1407 New York, NY 10019 US
- 代理机构： Bittner, Bernhard
- 优先权： US201461990807P 20140509
- 国际公布： WO2015172147 20151112
- 主分类号： C12N15/85
- IPC分类号： C12N15/85
摘要：
A method of delivering a transgene to a cell is provided. The method uses a vector that contains a T-cell receptor alpha locus control region (TCRαLCR) derived gene regulatory cassette having fewer than 5.0-kb. The method delivers the transgene with spatiotemporally specific gene expression and silencing-prevention controls to a cell such that a predetermined subset of progeny cell-types express a gene product from the transgene. Other progeny of the cell diminish, or silence, the expression of the gene product.
公开/授权文献
- EP3140407B1 TCR(ALPHA)-LCR-DERIVED GENE REGULATORY CASSETTES 公开/授权日：2020-03-18
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