发明公开
EP3145482A1 BIOSYNTHETIC PRODUCTION OF ACYL AMINO ACIDS
审中-公开
BIOSYNTHETISCHE PRODUKTION VONACYLAMINOSÄUREN
- 专利标题: BIOSYNTHETIC PRODUCTION OF ACYL AMINO ACIDS
- 专利标题(中): BIOSYNTHETISCHE PRODUKTION VONACYLAMINOSÄUREN
-
申请号: EP15721610.2申请日: 2015-04-28
-
公开(公告)号: EP3145482A1公开(公告)日: 2017-03-29
- 发明人: REINECKE, Liv , SCHAFFER, Steffen , GRAMMANN, Katrin , OLFERT, Maik , DECKER, Nicole , ARTO, Nils , HENNEMANN, Hans-Georg
- 申请人: Evonik Degussa GmbH
- 申请人地址: Rellinghauser Straße 1-11 45128 Essen DE
- 专利权人: Evonik Degussa GmbH
- 当前专利权人: Evonik Degussa GmbH
- 当前专利权人地址: Rellinghauser Straße 1-11 45128 Essen DE
- 优先权: EP14169650 20140523; EP14182110 20140825
- 国际公布: WO2015176922 20151126
- 主分类号: A61K8/44
- IPC分类号: A61K8/44 ; C12N9/00 ; C12N9/10 ; C12P13/04
摘要:
The present invention relates to a cell for producing acyl glycinateswherein the cell is genetically modified to comprise -at least a first genetic mutation that increases the expression relative to the wild type cell of an amino acid-N-acyl-transferase, -at least a second genetic mutation that increases the expression relative to the wild type cell of an acyl-CoA synthetase, and -at least a third genetic mutation that decreases the expression relative to the wild type cell of at least one enzyme selected from the group consisting of an enzyme of the glycine cleavage system, glycine hydroxymethyltransferase (GlyA) and threoninealdolase (LtaE).
信息查询