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    BIOSYNTHETIC PRODUCTION OF ACYL AMINO ACIDS
    1.
    发明公开
    BIOSYNTHETIC PRODUCTION OF ACYL AMINO ACIDS 审中-公开
    BIOSYNTHETISCHE PRODUKTION VONACYLAMINOSÄUREN

    公开(公告)号：EP3145482A1

    公开(公告)日：2017-03-29

    申请号：EP15721610.2

    申请日：2015-04-28

    申请人： Evonik Degussa GmbH

    发明人： REINECKE, Liv ,  SCHAFFER, Steffen ,  GRAMMANN, Katrin ,  OLFERT, Maik ,  DECKER, Nicole ,  ARTO, Nils ,  HENNEMANN, Hans-Georg

    IPC分类号： A61K8/44 ,  C12N9/00 ,  C12N9/10 ,  C12P13/04

    CPC分类号： C12P13/005 ,  C12N9/1014 ,  C12N9/1029 ,  C12N9/88 ,  C12N9/93 ,  C12P13/02 ,  C12Y201/02001 ,  C12Y203/01065 ,  C12Y401/02005 ,  C12Y602/01 ,  C12Y602/01001

    摘要： The present invention relates to a cell for producing acyl glycinateswherein the cell is genetically modified to comprise -at least a first genetic mutation that increases the expression relative to the wild type cell of an amino acid-N-acyl-transferase, -at least a second genetic mutation that increases the expression relative to the wild type cell of an acyl-CoA synthetase, and -at least a third genetic mutation that decreases the expression relative to the wild type cell of at least one enzyme selected from the group consisting of an enzyme of the glycine cleavage system, glycine hydroxymethyltransferase (GlyA) and threoninealdolase (LtaE).

    摘要翻译： 本发明涉及一种用于生产酰基甘氨酸盐的细胞，其中该细胞被遗传修饰为至少包含增加相对于氨基酸-N-酰基转移酶的野生型细胞的表达的第一种遗传突变，至少一种 增加相对于酰基-CoA合成酶的野生型细胞的表达的第二遗传突变，以及 - 至少一种第三遗传突变，其降低相对于所述野生型细胞的至少一种酶的表达，所述至少一种酶选自 甘氨酸切割系统的酶，甘氨酸羟甲基转移酶（GlyA）和苏氨酸醛酸酶（LtaE）。

    A METHOD FOR PRODUCING ACYL AMINO ACIDS
    2.
    发明公开
    A METHOD FOR PRODUCING ACYL AMINO ACIDS 审中-公开
    VERFAHREN ZUR HERSTELLUNG VONACYLAMINOSÄUREN

    公开(公告)号：EP3038595A1

    公开(公告)日：2016-07-06

    申请号：EP14755659.1

    申请日：2014-08-25

    申请人： Evonik Degussa GmbH

    发明人： GRAMMANN, Katrin ,  WOLTER, Jan ,  SCHAFFER, Steffen ,  CORTHALS, Jasmin ,  HAAS, Thomas ,  POTGRAVE, Nicole ,  REINECKE, Liv ,  OLFERT, Maik

    IPC分类号： A61K8/44 ,  C12N9/00 ,  C12N9/10 ,  C12P13/04

    CPC分类号： C12N9/1029 ,  C12N9/00 ,  C12N9/10 ,  C12N9/93 ,  C12P7/64 ,  C12P13/02 ,  C12P13/04 ,  C12Y203/01065 ,  C12Y203/01086

    摘要： The present invention relates to a cell expressing an amino acid-N-acyl-transferase, which is preferably recombinant, and an acyl-CoA synthetase, which is preferably recombinant, wherein the cell has a reduced fatty acid degradation capacity, a method for producing acyl amino acids, comprising the step contacting an amino acid and an acyl CoA in the presence of an amino acid-N-acyl-transferase, which is preferably isolated and/or recombinant, wherein the amino acid-N-acyl-transferase is preferably a human amino acid-N-acyl-transferase, or culturing the cell and a reaction mixture comprising an amino acid-N-acyl-transferase, which is preferably isolated and/or recombinant, an acyl-CoA synthetase, which is preferably isolated and/or recombinant, an amino acid and either a fatty acid-CoA or a fatty acid and an acyl-CoA-synthase.

    摘要翻译： 本发明涉及优选重组的表达氨基酸-N-酰基转移酶的细胞和优选重组的酰基辅酶A合成酶，其中所述细胞具有降低的脂肪酸降解能力，生产方法 酰基氨基酸，其包含在优选分离和/或重组的氨基酸-N-酰基转移酶存在下使氨基酸和酰基辅酶A接触的步骤，其中氨基酸-N-酰基转移酶优选为 人氨基酸N-酰基转移酶或培养细胞，以及包含优选分离和/或重组的氨基酸-N-酰基转移酶的反应混合物，其优选分离和 /或重组体，氨基酸和脂肪酸-CoA或脂肪酸和酰基辅酶A合成酶。