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发明公开
EP3153863A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
方法和组合物诊断和预后判断肾功能衰竭和肾损害

  • 专利标题： METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
  • 专利标题（中）： 方法和组合物诊断和预后判断肾功能衰竭和肾损害
  • 申请号： EP16196505.8
    申请日： 2010-11-05
  • 公开(公告)号： EP3153863A1
    公开(公告)日： 2017-04-12
  • 发明人: ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James Patrick
  • 申请人： Astute Medical, Inc.
  • 申请人地址： Blg 2 R. 645 3550 General Atomics Court San Diego, CA 92121 US
  • 专利权人： Astute Medical, Inc.
  • 当前专利权人： Astute Medical, Inc.
  • 当前专利权人地址： Blg 2 R. 645 3550 General Atomics Court San Diego, CA 92121 US
  • 代理机构： Schiweck, Weinzierl & Koch Patentanwälte Partnerschaft mbB
  • 优先权： US259155P 20091107; US259157P 20091107; US259162P 20091107; US259147P 20091107; US259152P 20091107; US259136P 20091107; US259137P 20091107; US259160P 20091107; US259159P 20091107; US259135P 20091107; US259139P 20091107; US259153P 20091107; US259151P 20091107; US259148P 20091107; US259156P 20091107; US259161P 20091107; US259145P 20091107; US285928P 20091211; US285929P 20091211; US320723P 20100403; US346547P 20100520; US346551P 20100520
  • 主分类号： G01N33/68
  • IPC分类号： G01N33/68
METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
摘要：
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect soluble Transmembrane glycoprotein NMB, and optionally further a kidney injury marker of C-C motif chemokine 23, Brain-derived neurotrophic factor, Cathepsin S, Transforming growth factor beta-2, Urokinase-type plasminogen activator, Angiopoietin-2, Matrilysin, Carcinoembryonic antigen-related cell adhesion molecule 1, Creatine kinase MB, Insulin, Immunoglobulin M, Immunoglobulin E, Macrophage migration inhibitory factor, Galectin-3, Transforming growth factor beta-3, Heparan sulfate, soluble Cadherin-3, Complement C5, Platelet factor 4, Platelet basic protein, and Stromelysin-2 as diagnostic and prognostic biomarkers in renal injuries.
摘要（中）：

本发明涉及一种用于在患有或疑似患有肾损伤的受试者监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及一种使用经配置以检测可溶性跨膜糖蛋白NMB一个一种或多种测定，并且任选地进一步肾损伤标记物CC基序趋化因子23，脑源性神经营养因子，组织蛋白酶S的，转化生长因子β-2， 尿激酶型纤维蛋白溶酶原活化剂，血管生成素-2，基质溶素，癌胚抗原相关细胞粘附分子1，肌酸激酶MB，胰岛素，免疫球蛋白男，免疫球蛋白E，巨噬细胞迁移抑制因子，半乳糖凝集素-3，转化生长因子β-3，类肝素 硫酸盐，可溶性钙粘蛋白3，补体C5，血小板因子4，血小板碱性蛋白，和溶基质蛋白酶-2在肾损伤作为诊断和预后标志物。

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