发明公开
- 专利标题： PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
- 专利标题（中）： 磷脂酰肌醇3-激酶缝边
-
申请号： EP15739079.0申请日： 2015-06-23
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公开(公告)号： EP3160960A1公开(公告)日： 2017-05-03
- 发明人: EVARTS, Jerry , KAPLAN, Joshua , KIM, Musong , NADUTHAMBI, Devan , PATEL, Leena , PERRAULT, Stephane , PHILLIPS, Gary , PURVIS, Lafe, J., II , STEVENS, Kirk, L. , TREIBERG, Jennifer, A.
- 申请人： GILEAD SCIENCES, INC.
- 申请人地址： 333 Lakeside Drive Foster City, CA 94404 US
- 专利权人： GILEAD SCIENCES, INC.
- 当前专利权人： GILEAD SCIENCES, INC.
- 当前专利权人地址： 333 Lakeside Drive Foster City, CA 94404 US
- 代理机构： Schnappauf, Georg
- 优先权： US201462016194P 20140624
- 国际公布： WO2015200352 20151230
- 主分类号： C07D403/12
- IPC分类号： C07D403/12 ; C07D401/14 ; C07D413/14 ; C07D403/14 ; C07D409/14 ; C07D491/107 ; A61K31/517 ; A61P35/00 ; A61P37/00 ; A61P29/00
摘要：
The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (J), or pharmaceutically acceptable salts thereof, in which A, n, m, R
1 , R
2 , R
3 R
4 , R
5 , R
6 and R
7 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more ΡI3Κ isoforms. The present disclosure further provides pharmaceutical compositions that include a compound of formula (J), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms.
1 , R
2 , R
3 R
4 , R
5 , R
6 and R
7 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more ΡI3Κ isoforms. The present disclosure further provides pharmaceutical compositions that include a compound of formula (J), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms.
公开/授权文献
- EP3160960B1 PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS 公开/授权日：2021-10-13
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